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CAS RN: 122647-32-9 | 产品编码: I0946
Ibutilide Hemifumarate
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| 产品编码 | I0946 |
| 纯度/分析方法 | >98.0%(HPLC)(N) |
| 分子式/分子量 | C__2__0H__3__6N__2O__3S·^^1/__2C__4H__4O__4 = 442.62 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| 包装和容器 | 100MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 122647-32-9 |
| 相关CAS RN | 122647-31-8 |
| PubChem物质ID | 253662069 |
| Merck Index (14) | 4883 |
| MDL编号 | MFCD01715410 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| NMR | confirm to structure |
物性（参考值）
| 最大吸收波长 | 267(EtOH) nm |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H302 : Harmful if swallowed. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相关法规
| RTECS# | PB0475700 |
运输信息
| HS编码* | 2935.90-000 |
应用
Ibutilide Fumarate: The First "Pure" Class III Antiarrhythmic Agent
Ibutilide fumarate, the first "pure" class III antiarrhythmic agent, is shown to increase the refractory period and action potential duration of myocardial cells. At a cellular level, ibutilide fumarate exerts two main actions: dihydropyridine Ca2+ channel blockers and potent inhibition of the delayed rectifier K+ current (IKr), by binding within the channel pore cavity upon channel gating. (The product is for research purpose only.)
References
- Ibutilide, a new compound with potent class III antiarrhythmic activity, activates a slow inward sodium current in guinea pig ventricular cells
- Ibutilide, a methanesulfonanilide antiarrhythmic, is a potent blocker of the rapidly activating delayed rectifier K+ current (IKr) in AT-1 cells: concentration-, time-, voltage-, and use-dependent effects
- Ibutilide (a review)
- Structural determinants of HERG channel block by clofilium and ibutilide
- Cardioversion of persistent atrial fibrillation by a combination of atrial specific and non-specific class III drugs in the goat
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