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CAS RN: 482-44-0 | 产品编码: I0904
Imperatorin
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| 产品编码 | I0904 |
| 纯度/分析方法 | >98.0%(HPLC) |
| 分子式/分子量 | C__1__6H__1__4O__4 = 270.28 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷冻 (<0°C) |
| 应避免的情况 | 加热 |
| 包装和容器 | 100MG-Glass Bottle with Plastic Insert （查看图片）, 25MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 482-44-0 |
| Reaxys-RN | 249728 |
| PubChem物质ID | 354334057 |
| Merck Index (14) | 4925 |
| MDL编号 | MFCD00016881 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 97.0 to 101.0 °C |
物性（参考值）
| 熔点 | 99 °C |
| 最大吸收波长 | 301(MeOH) nm |
| 水溶性 | 不溶 |
| 溶解性（可溶于） | 乙醚, 丙酮, 醇, 苯 |
GHS
相关法规
| RTECS# | LV1575000 |
运输信息
| HS编码* | 2932.20-000 |
应用
Imperatorin: An Inhibitor of Cyclin D1 Expression
Imperatorin is a furanocoumarin and a phytochemical isolated from herbal medicines such as Angelica dahurica. Imperatorin strongly inhibits cyclin D1 expression and arrests the cells at the G1 phase of the cell cycle. It is reported that imperatorin shows potent pharmacological activities including anticonvulsant, vasodilatation, antitumor, anti-inflammatory activities and affecting the activities of drug-metabolizing enzymes. (The product is for research purpose only.)
References
- Imperatorin Inhibits HIV-1 Replication through an Sp1-dependent Pathway
- Anticonvulsant and acute neurotoxic effects of imperatorin, osthole and valproate in the maximal electroshock seizure and chimney tests in mice: A comparative study
- Imperatorin induces vasodilatation possibly via inhibiting voltage dependent calcium channel and receptor-mediated Ca2+ influx and release
- Anticancer effects of imperatorin isolated from Angelica dahurica: induction of apoptosis in HepG2 cells through both death-receptor- and mitochondria-mediated pathways
- Inducible Nitric Oxide Synthase and Cyclooxygenase-2 Participate in Anti-inflammatory Activity of Imperatorin from Glehnia littoralis
- Simultaneous determination of scopoletin, psoralen, bergapten, xanthotoxin, columbianetin acetate, imperatorin, osthole and isoimperatorin in rat plasma by LC-MS/MS for pharmacokinetic studies following oral administration of Radix Angelicae Pubescentis extract
- Solubility of imperatorin in ethanol + water mixtures
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