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CAS RN: 26833-87-4 | 产品编码: H1775
Homoharringtonine
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纯度/分析方法: >98.0%(HPLC)
别名：
- 高三尖杉酯碱
- 三尖杉碱4-甲基(2R)-2-羟基-2-(4-羟基-4-甲基戊基)丁二酸酯
- O3-[(2R)-2,6-二羟基-2-(2-甲氧基-2-氧代乙基)-6-甲基庚酰基]三尖杉碱
- Cephalotaxine 4-Methyl (2R)-2-Hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate
- O3-[(2R)-2,6-Dihydroxy-2-(2-methoxy-2-oxoethyl)-6-methylheptanoyl]cephalotaxine
产品文档：
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 144.0 to 148.0 °C |
| Specific rotation | -119 to -125deg (C=0.3, CHCl3) |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 146 °C |
GHS
| 象形图 |
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| 信号词 | Danger |
| 危险性说明 | H300 : Fatal if swallowed. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
相关法规
| RTECS# | FK0260000 |
运输信息
| UN编号 | UN1544 |
| 类别 | 6.1 |
| 包装类别 | II |
| HS编码* | 2939.79-000 |
应用
Homoharringtonine: A Cephalotaxine Alkaloid with Antiviral and Anticancer Activities
Homoharringtonine is a cephalotaxine alkaloid originally found in Cephalotaxus hainanensis L.1) Homoharringtonine exhibits antiviral and anticancer activities, and immobilized ribosomes immediately after initiation of translation in eukaryotic systems. It has been reported that homoharringtonine induces apoptosis in human promyelocytic leukemic HL-60 cells.2,3) Therefore, homoharringtonine has been used for the treatment of chronic myeloid leukemia (CML). (The product is for research purpose only.)
References
- 1) Structures of harringtonine, isoharringtonine, and homoharringtonine
- 2) Homoharringtonine: history, current research, and future direction (a review)
- 3) Homoharringtonine, omacetaxine mepesuccinate, and chronic myeloid leukemia circa 2009 (a review)
- 4) From traditional Chinese medicine to traditional cancer therapy (a review)
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技术规格
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