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CAS RN: 149647-78-9 | 产品编码: H1388
N-Hydroxy-N'-phenyloctanediamide
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技术规格
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
物性（参考值）
| 熔点 | 155 °C |
| 在水中的溶解度 | 1,167 mg/l 25 °C |
| 溶解性（微溶于） | 乙醇, 丙酮 |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H361 : Suspected of damaging fertility or the unborn child. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
相关法规
| RTECS# | RG8835000 |
运输信息
| HS编码* | 2928.00-000 |
应用
Hypoxia inducible factor (HIF) research / Hypoxia inducible factor (HIF) inhibitor
Reference
- Epigenetic re-expression of HIF-2α suppresses soft tissue sarcoma growth.
应用
Reticulophagy research / ER (endoplasmic reticulum) phagy
Reference
- Suberoylanilide hydroxamic acid upregulates reticulophagy receptor expression and promotes cell death in hepatocellular carcinoma cells
应用
Adeno-associated virus vector transduction enhancer
N-Hydroxy-N'-phenyloctanediamide (Vorinostat) increases transduction by adeno-associated virus (AAV) vectors.1)
References
- 1) Identification and validation of small molecules that enhance recombinant adeno-associated virus transduction following high-throughput screens
应用
HDAC Inhibitor
Suberoylanilidehydroxamic acid (SAHA) is a histone deacetylase (HDAC) inhibitor1,2) and inhibits both classes I and II enzymes by binding to the pocket of the catalytic site.3) The compound has been demonstrated to inhibit the proliferation of a wide variety of transformed cells in vitro.1)
References
- 1) Cancer biology: mechanism of antitumor action of vorinostat (suberoylanilide hydroxamic acid), a novel histone deacetylase inhibitor
- 2) A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases
- 3) Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors
参考文献
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技术规格
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