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CAS RN: 747-36-4 | 产品编码: H1306
Hydroxychloroquine Sulfate
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纯度/分析方法: >98.0%(HPLC)(N)
别名：
- 硫酸羟基氯喹
- 7-氯-4-[4-[N-乙基-N-(2-羟乙基)氨基]-1-甲基丁基氨基]喹啉硫酸盐
- N4-(7-氯-4-喹啉基)-N1-乙基-N1-(2-羟乙基)-1,4-戊二胺硫酸盐
- 7-Chloro-4-[4-[N-ethyl-N-(2-hydroxyethyl)amino]-1-methylbutylamino]quinoline Sulfate
- N4-(7-Chloro-4-quinolyl)-N1-ethyl-N1-(2-hydroxyethyl)-1,4-pentanediamine Sulfate
产品文档：
| 规格 | 单价 | 同一天 | 2-3个工作日 | 数量 |
|---|---|---|---|---|
| 5G |
S$118.50
|
25 | ≥100 |
|
| 25G |
S$393.00
|
5 | 14 |
|
补充产品信息:
This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| NMR | confirm to structure |
物性（参考值）
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H302 : Harmful if swallowed. H319 : Causes serious eye irritation. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相关法规
| RTECS# | KK3342500 |
运输信息
| HS编码* | 2933.49-000 |
应用
Adeno-associated virus vector transduction enhancer
Hydroxychloroquine increases transduction by adeno-associated virus (AAV) vectors.1)
References
- 1) Enhancement of adeno-associated virus-mediated gene therapy using hydroxychloroquine in murine and human tissues
应用
Hydroxychloroquine Sulfate: A Derivative of 4-Aminoquinoline with Autophagy Inhibitory, Antimalarial and Anticancer Activities
Hydroxychloroquine sulfate is a derivative of 4-aminoquinoline, which is an inhibitor of autophagy and has antimalarial, anticancer and anti-rheumatoid activities. The mechanism of action of chloroquine is not completely understood. But, some studies have demonstrated that hydroxychloroquine is a weak base and may exert its effect by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme. In addition, while hydroxychloroquine can inhibit certain enzymes, its effect is believed to result, at least in part from its interaction with DNA. (The product is for research purpose only.)
References
- The Role of Autophagy in Cancer: Therapeutic Implications
- Targeting autophagy in cancer (a review)
- Antimalarial Agents: Chloroquine, Hydroxychloroquine, and Quinacrine (a review)
- Hydroxychloroquine: from malaria to autoimmunity
- Treatment of rheumatoid arthritis with methotrexate alone, sulfasalazine and hydroxychloroquine, or a combination of all three medications
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