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CAS RN: 304-20-1 | 产品编码: H0409
1-Hydrazinophthalazine Hydrochloride
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技术规格
Appearance | White to Almost white powder to crystal |
Purity(HPLC) | min. 99.0 area% |
Purity( Potassium iodate Method) | min. 99.0 % |
Solubility in Water | almost transparency |
物性(参考值)
熔点 | 273 °C(dec.) |
水溶性 | 可溶 |
在水中的溶解度 | 44.2 g/l 25 °C |
GHS
象形图 |
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信号词 | Danger |
危险性说明 | H301 : Toxic if swallowed. H361 : Suspected of damaging fertility or the unborn child. H362 : May cause harm to breast-fed children. |
防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P263 : Avoid contact during pregnancy/ while nursing. P260 : Do not breathe dusts or mists. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
相关法规
RTECS# | TH9000000 |
运输信息
UN编号 | UN2811 |
类别 | 6.1 |
包装类别 | III |
HS编码* | 2933.99-000 |
应用
Hydralazine Hydrochloride: A Vasodilator in Arterioles
Although the precise mechanism of action is not fully under-stood, hydralazine hydrochloride exerts its peripheral vasodilating effect through a direct relaxation of smooth muscle tissue in vascular resistance vessels, predominantly in the arterioles, and resulting in decreased blood pressure. Recently, the property of hydralazine has been reported, such as a DNA methylation inhibitor, an antioxidant and etc. (The product is for research purpose only.)
References
- Hydralazine and isosorbide dinitrate in heart failure: historical perspective, mechanisms, and future directions (a review)
- Hydralazine and procainamide inhibit T cell DNA methylation and induce autoreactivity
- Molecular Modeling and Molecular Dynamics Studies of Hydralazine with Human DNA Methyltransferase 1
- Hydralazine prevents nitroglycerin tolerance by inhibiting activation of a membrane-bound NADH oxidase. A new action for an old drug
- Hydralazine hydrochloride (a review including physical properties, synthesis, stability, metabolism and methods of analyzing)
- Spectrophotometric determination of hydralazine using p-dimethylaminobenzaldehyde
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