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CAS RN: 95975-55-6 | 产品编码: G0629
Guggulsterone [mixture of (E)- and (Z)- isomers]
纯度/分析方法: >98.0%(HPLC)
别名:
- 香胶甾酮 [(E)-和(Z)-异构体混合物]
- 孕甾-4,17(20)-二烯-3,16-二酮 [(E)-和(Z)-异构体混合物]
- 孕甾-4,17-二烯-3,16-二酮 [(E)-和(Z)-异构体混合物]
- Pregna-4,17(20)-diene-3,16-dione [mixture of (E)- and (Z)- isomers]
- Pregna-4,17-diene-3,16-dione [mixture of (E)- and (Z)- isomers]
产品文档:
产品编码 | G0629 |
纯度/分析方法 | >98.0%(HPLC) |
分子式/分子量 | C__2__1H__2__8O__2 = 312.45 |
外观与形状(20°C) | 固体 |
储存温度 | 室温 (15°C以下阴凉干燥处) |
CAS RN | 95975-55-6 |
Reaxys-RN | 5294518 |
MDL编号 | MFCD01310757 |
技术规格
Appearance | White to Light yellow powder to crystal |
Purity(HPLC) | min. 98.0 %(total of isomers) |
NMR | confirm to structure |
物性(参考值)
GHS
相关法规
RTECS# | TU3670500 |
运输信息
HS编码* | 2914.29-000 |
应用
Guggulsterone: A Bioactive Plant Sterol
Guggulsterone is a plant sterol and bioactive compound found in the gum guggul of Commiphora wightii, which has been used as a traditional herbal medicine. Guggulsterone has been reported to bind to the farnesoid X receptor (FXR), a member of the nuclear hormone receptor superfamily, and decrease the expression of bile acid-activated genes.1) Guggulsterone has been found to potently inhibit the activation of nuclear factor-κB (NF-κB), a critical regulator of inflammatory responses.1) Furthermore, guggulsterone modulates the expression of proteins with anti-apoptotic (IAP1, XIA, P, Bfl-1/A1, Bcl-2, cFLIP, survivin), cell survival, cell proliferation (cyclin D1, c-Myc), angiogenic, and metastatic (MMP-9, COX-2, VEGF) activities in tumor cells.1-5) (The product is for research purpose only.)
References
- 1) Guggulsterone inhibits NF-κB and IκBα kinase activation, suppresses expression of anti-apoptotic gene products, and enhances apoptosis
- 2)Therapeutic effects of guggul and its constituent guggulsterone: cardiovascular benefits (a review)
- 3) Guggulsterone and Its Role in Chronic Diseases (a review)
- 4) Guggulsterone for Chemoprevention of Cancer (a review)
- 5) Pharmacologic activities of phytosteroids in inflammatory diseases: Mechanism of action and therapeutic potentials
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