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CAS RN: 12542-36-8 | 产品编码: G0543
Gossypol Acetic Acid
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纯度/分析方法: >98.0%(T)(HPLC)
别名：
- 醋酸棉酚
- 1,1',6,6',7,7'-六羟基-5,5'-二异丙基-3,3'-二甲基-[2,2'-联二萘]-8,8'-二甲醛醋酸盐
- 2,2'-双(8-甲酰基-1,6,7-三羟基-5-异丙基-3-甲基萘)醋酸盐
- 1,1',6,6',7,7'-Hexahydroxy-5,5'-diisopropyl-3,3'-dimethyl-[2,2'-binaphthalene]-8,8'-dicarbaldehyde Acetic Acid
- 2,2'-Bis(8-formyl-1,6,7-trihydroxy-5-isopropyl-3-methylnaphthalene) Acetic Acid
产品文档：
| 产品编码 | G0543 |
| 纯度/分析方法 | >98.0%(T)(HPLC) |
| 分子式/分子量 | C__3__0H__3__0O__8·C__2H__4O__2 = 578.61 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷藏 (0-10°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 湿气 (吸湿),加热 |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片）, 250MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 12542-36-8 |
| PubChem物质ID | 468591926 |
| Merck Index (14) | 4528 |
| MDL编号 | MFCD00058385 |
技术规格
| Appearance | White to Green to Brown powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
物性（参考值）
| 熔点 | 168 °C(dec.) |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H361 : Suspected of damaging fertility or the unborn child. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
相关法规
| RTECS# | MD7360000 |
运输信息
| HS编码* | 2915.39-000 |
应用
Gossypol Acetic Acid: A Polyphenolic Compound with Anti-Tumor, Anti-Viral, and Anti-Spermatogenic Properties
Gossypol acetic acid (gossypol) is a polyphenolic compound found in the cotton plant (genus Gossypium).1-4) Gossypol is of medical interest because of its anti-tumor,1,4) anti-viral,2) and anti-spermatogenic3) properties. Because of the restricted rotation of the two naphthyl moieties, which are connected via a C-C bond, gossypol exists as (+) and (-) enantiomers, in spite of the absence of an asymmetric carbon.2) Biological studies shows that the (-) enantiomer of gossypol was more active than the (+) form.1,2) The (-) enantiomer, named AT-101, is expected to be a new antitumor agent.5,6) (The product is for research purpose only.)
References
- 1) Cytotoxicity of enantiomers of gossypol
- 2) Selective inhibition of human immunodeficiency virus type 1 replication by the (-) but not the (+) enantiomer of gossypol
- 3) In vitro effect of gossypol acetate on yellow perch (Perca flavescens) spermatozoa
- 4) Gossypol reduction of tumor growth through ROS-dependent mitochondria pathway in human colorectal carcinoma cells
- 5) AT-101 induces apoptosis in CLL B cells and overcomes stromal cell-mediated Mcl-1 induction and drug resistance
- 6) Chemoresistance is associated with increased cytoprotective autophagy and diminished apoptosis in bladder cancer cells treated with the BH3 mimetic (-)-Gossypol (AT-101).
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