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CAS RN: 873857-62-6 | 产品编码: F1216
Fidaxomicin
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| 产品编码 | F1216 |
| 纯度/分析方法 | >98.0%(HPLC) |
| 分子式/分子量 | C__5__2H__7__4Cl__2O__1__8 = 1,058.05 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷藏 (0-10°C) |
| 应避免的情况 | 加热 |
| 包装和容器 | 100MG-Glass Bottle with Plastic Insert （查看图片）, 25MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 873857-62-6 |
| Reaxys-RN | 12687773 |
| PubChem物质ID | 468591852 |
| MDL编号 | MFCD27976367 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
物性（参考值）
| 熔点 | 161 °C |
| 比旋光度 [α]D | -6.9° (C=2,MeOH) |
GHS
相关法规
运输信息
| HS编码* | 2941.90-000 |
应用
Fidaxomicin: A Narrow-Spectrum Macrolide Antibiotic Active against Clostridia
Fidaxomicin (OPT-80) is a narrow-spectrum macrolide antibiotic obtained from the Actinomycete Dactylosporangium aurantiacum. Fidaxomicin is active primarily against species of clostridia, including Clostridium difficile (or Clostridioides difficile) that is a major cause of hospital-acquired diarrhea and mortality in individuals. Fidaxomicin has demonstrated potent in vitro bactericidal activity, inhibiting RNA synthesis by RNA polymerases, with limited or no activity against normal fecal flora. In addition, it is minimally absorbed from the intestinal tract. (The product is for research purpose only.)
文献
- OPT-80 Eliminates Clostridium difficile and Is Sparing of Bacteroides Species during Treatment of C. difficile Infection
- A new macrocyclic antibiotic, fidaxomicin (OPT-80), causes less alteration to the bowel microbiota of Clostridium difficile-infected patients than does vancomycin
- Antimicrobial Activities of Fidaxomicin (a review)
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