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CAS RN: 436-77-1 | 产品编码: F1173
Fangchinoline
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| 产品编码 | F1173 |
| 纯度/分析方法 | >97.0%(HPLC) |
| 分子式/分子量 | C__3__7H__4__0N__2O__6 = 608.74 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷藏 (0-10°C) |
| 应避免的情况 | 加热 |
| 包装和容器 | 20MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 436-77-1 |
| Reaxys-RN | 78975 |
| PubChem物质ID | 468591833 |
| MDL编号 | MFCD00221726 |
技术规格
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Elemental analysis(Nitrogen) | 4.00 to 5.00 % |
物性（参考值）
| 熔点 | 238 °C(dec.) |
| 最大吸收波长 | 283(EtOH) nm |
GHS
相关法规
| RTECS# | DR9280000 |
运输信息
| HS编码* | 2939.79-000 |
应用
Fangchinoline: An Alkaloid with Diverse Pharmacological Effects Including Significant Antitumor Activities
Fangchinoline and tetrandrine [T3321] are the major alkaloids from Stephenia tetrandra S Moore which is a plant indigenous to main land of China that has long been used as a Chinese herb. Stephenia tetrandra S Moore is traditionally used as analgesic, antirheumatic, and antihypertensive drug.1,2) Recently, fangchinoline has been found to exhibit diverse pharmacological effects including significant antitumor activities.3-5) (The product is for research purpose only.)
References
- 1) Vasodilating and hypotensive effects of fangchinoline and tetrandrine on the rat aorta and the stroke-prone spontaneously hypertensive rat
- 2) Anti-inflammatory effects of fangchinoline and tetrandrine
- 3) Fangchinoline induced G1/S arrest by modulating expression of p27, PCNA, and cyclin D in human prostate carcinoma cancer PC3 cells and tumor xenograft
- 4) Fangchinoline induces autophagic cell death via p53/sestrin2/AMPK signalling in human hepatocellular carcinoma cells
- 5) Molecular targets modulated by fangchinoline in tumor cells and preclinical models (a review)
- 6) Detection of aristolochic acid I, tetrandrine and fangchinoline in medicinal plants by high performance liquid chromatography and liquid chromatography/mass spectrometry
- 7) Determination of tetrandrine and fangchinoline in plasma samples using hollow fiber liquid-phase microextraction combined with high-performance liquid chromatography
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