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CAS RN: 6990-06-3 | 产品编码: F1007
Fusidic Acid
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| 产品编码 | F1007 |
| 纯度/分析方法 | >97.0%(T)(HPLC) |
| 分子式/分子量 | C__3__1H__4__8O__6 = 516.72 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷藏 (0-10°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 湿气 (吸湿),加热 |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 6990-06-3 |
| Reaxys-RN | 2197692 |
| PubChem物质ID | 253660799 |
| Merck Index (14) | 4317 |
| MDL编号 | MFCD00865135 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(Neutralization titration) | min. 97.0 % |
| Specific rotation [a]20/D | -6.0 to -10.0 deg(C=1,CHCl3) |
物性（参考值）
| 熔点 | 193 °C |
| 比旋光度 [α]D | -7° (C=1,CHCl3) |
| 最大吸收波长 | 204(H2O) nm |
| 溶解性（可溶于） | 二噁烷, 醇, 氯仿, 丙酮 |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H302 : Harmful if swallowed. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相关法规
| RTECS# | RC1350000 |
运输信息
| HS编码* | 2941.90-000 |
应用
Fusidic Acid: An Inhibitor of the Elongation Factor G (EF-G)
Fusidic acid, a steroidal antibiotic agent, is derived from the fungus Fusidium coccineum. The elongation factor G (EF-G) catalyzes the translocation of the tRNA and mRNA down the ribosome at the end of each round of polypeptide elongation. Fusidic acid binds to EF-G, preventing its release from the ribosome, thus stalling bacterial protein synthesis. Fusidic acid is mainly notable for its activity against staphylococci, whether or not they are resistant to methicillin and related penicillins.
References
- Structure-activity relationships in fusidic acid-type antibiotics (a review)
- The antimicrobial activity of fusidic acid (a review)
- Fusidic acid pharmacology, pharmacokinetics and pharmacodynamics (a review)
- Structure of a mutant EF-G reveals domain III and possibly the fusidic acid binding site
- Dumb and dumber-the potential waste of a useful antistaphylococcal agent: emerging fusidic acid resistance in Staphylococcus aureus (a review)
- Characterization of Global Patterns and the Genetics of Fusidic Acid Resistance (a review)
参考文献
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