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CAS RN: 269055-15-4 | 产品编码: E1528
Etravirine
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纯度/分析方法: >95.0%(T)(HPLC)
别名：
- 依曲韦林
- 4-[[6-氨基-5-溴-2-(4-氰基苯胺基)-4-嘧啶基]氧基]-3,5-二甲基苯甲腈
- 4-[[6-氨基-5-溴-2-[(4-氰基苯基)氨基]嘧啶-4-基]氧基]-3,5-二甲基苯甲腈
- 4-[[6-Amino-5-bromo-2-(4-cyanoanilino)-4-pyrimidinyl]oxy]-3,5-dimethylbenzonitrile
- 4-[[6-Amino-5-bromo-2-[(4-cyanophenyl)amino]pyrimidin-4-yl]oxy]-3,5-dimethylbenzonitrile
产品文档：
| 产品编码 | E1528 |
| 纯度/分析方法 | >95.0%(T)(HPLC) |
| 分子式/分子量 | C__2__0H__1__5BrN__6O = 435.29 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷冻 (<0°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 空气,加热 |
| 包装和容器 | 100MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 269055-15-4 |
| Reaxys-RN | 8945855 |
| MDL编号 | MFCD09837879 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(Nonaqueous Titration) | min. 95.0 % |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 254 °C |
| 水溶性 | 不溶 |
| 溶解性（可溶于） | 二甲基甲酰胺 |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H302 : Harmful if swallowed. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相关法规
| RTECS# | DI2457260 |
运输信息
| HS编码* | 2933.59-000 |
应用
Etravirine: A Diarylpyrimidine NNRTI with Inherent Structural Flexibility
Etravirine (TMC125) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) of human immunodeficiency virus type 1 (HIV-1). Etravirine binds directly to reverse transcriptase (RT) and blocks RNA-dependent and DNA-dependent DNA polymerase activities by causing a disruption of the catalytic site of the enzyme. Diarylpyrimidine NNRTI, such as etravirine, have inherent structural flexibility, helping to maintain activity against a wide range of resistance mutations. On the other hand, etravirine does not inhibit the human DNA polymerases. (The product is for research purpose only.)
References
- Roles of Conformational and Positional Adaptability in Structure-Based Design of TMC125-R165335 (Etravirine) and Related Non-nucleoside Reverse Transcriptase Inhibitors That Are Highly Potent and Effective against Wild-Type and Drug-Resistant HIV-1 Variants
- TMC125, a novel next-generation nonnucleoside reverse transcriptase inhibitor active against nonnucleoside reverse transcriptase inhibitor-resistant human immunodeficiency virus type 1
- Crystal Structures of HIV-1 Reverse Transcriptase with Etravirine (TMC125) and Rilpivirine (TMC278): Implications for Drug Design
- Clinical perspective on antiretroviral drug-drug interactions with the non-nucleoside reverse transcriptase inhibitor etravirine (a review)
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技术规格
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