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CAS RN: 163222-33-1 | 产品编码: E1449
Ezetimibe
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| 产品编码 | E1449 |
| 纯度/分析方法 | >95.0%(T) |
| 分子式/分子量 | C__2__4H__2__1F__2NO__3 = 409.43 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷藏 (0-10°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 空气,加热 |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 163222-33-1 |
| Reaxys-RN | 7981967 |
| PubChem物质ID | 468591792 |
| MDL编号 | MFCD00937872 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Volumetric Analysis) | min. 95.0 % |
| Melting point | 162.0 to 166.0 °C |
| Specific rotation | -20.0 to -30.0 deg(C=3, Methanol) |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 163 °C |
| 最大吸收波长 | 285(CH3CN) nm |
| 水溶性 | 不溶 |
| 在水中的溶解度 | 4.4 mg/l 25 °C |
| 溶解性（可溶于） | 乙醇, 甲醇 |
GHS
相关法规
| RTECS# | CM4554000 |
运输信息
| HS编码* | 2933.79-000 |
应用
Ezetimibe: A Potent Inhibitor of Cholesterol Intestinal Absorption
Ezetimibe (SCH 58235) is in a class of lipid-lowering agents that selectively inhibits the intestinal absorption of cholesterol and related phytosterols. It has been reported that ezetimibe reduces the small intestinal enterocyte uptake and absorption of cholesterol by binding to a cholesterol transporter Niemann-Pick C1-Like 1 (NPC1L1) which is involved in the intestinal uptake of cholesterol and phytosterols, and keeps cholesterol in the intestinal lumen for excretion. (The product is for research purpose only.)
References
- Niemann-Pick C1 Like 1 Protein Is Critical for Intestinal Cholesterol Absorption
- The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1)
- Niemann-pick C1-like 1 (NPC1L1) protein in intestinal and hepatic cholesterol transport (a review)
- Zetia: inhibition of Niemann-Pick C1 like 1 (NPC1L1) to reduce intestinal cholesterol absorption and treat hyperlipidemia (a review)
- Development and validation of a reversed-phase HPLC method for the determination of ezetimibe in pharmaceutical dosage forms
- Stress degradation studies on ezetimibe and development of a validated stability-indicating HPLC assay
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