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CAS RN: 143664-11-3 | 产品编码: E1371
Elacridar
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| 产品编码 | E1371 |
| 纯度/分析方法 | >98.0%(HPLC) |
| 分子式/分子量 | C__3__4H__3__3N__3O__5 = 563.65 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷冻 (<0°C) |
| 应避免的情况 | 加热 |
| 包装和容器 | 100MG-Glass Bottle with Plastic Insert （查看图片）, 25MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 143664-11-3 |
| Reaxys-RN | 7324887 |
| PubChem物质ID | 468591739 |
| MDL编号 | MFCD00912604 |
技术规格
| Appearance | White to Yellow to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
物性（参考值）
| 熔点 | 210 °C |
GHS
| 危险性说明 | H413 : May cause long lasting harmful effects to aquatic life. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. |
相关法规
| RTECS# | AR7621300 |
运输信息
| HS编码* | 2933.99-000 |
应用
Elacridar: A Potent Dual Inhibitor of Breast Cancer Resistance Protein (BCRP) and P-Glycoprotein (P-gp)
Elacridar (GF120918) is a potent dual inhibitor of breast cancer resistance protein (BCRP) and P-glycoprotein (P-gp). BCPR is a member of ATP-binding cassette family of drug transporters. P-gp, known as multidrug resistance protein 1 (MDR1), is an ATP-binding protein of the cell membrane that pumps many foreign substances out of cells. Therefore, it is believed that elacridar increases oral bioavailability of topotecan, a topoisomerase inhibitor. (The product is for research purpose only.)
References
- In vitro and in vivo reversal of multidrug resistance by GF120918, an acridonecarboxamide derivative
- Role of breast cancer resistance protein in the bioavailability and fetal penetration of topotecan
- Therapeutic Potential and Utility of Elacridar with Respect to P-glycoprotein Inhibition: An Insight from the Published In Vitro, Preclinical and Clinical Studies (a review)
- Bioanalysis and preliminary pharmacokinetics of the acridonecarboxamide derivative GF120918 in plasma of mice and humans by ion-pairing reversed-phase high-performance liquid chromatography with fluorescence detection
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