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CAS RN: 107724-20-9 | 产品编码: E0905
Eplerenone
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| 规格 | 单价 | 同一天 | 2-3个工作日 | 左侧以上货期 | 数量 |
货期信息
|
|---|---|---|---|---|---|---|
| 200MG |
S$277.50
|
23 | 0 | 下单后约2周内可以发货 |
|
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
物性（参考值）
| 熔点 | 242 °C(dec.) |
| 最大吸收波长 | 240 nm |
| 溶解性（可溶于） | 氯仿, 二氯甲烷 |
| 溶解性（微溶于） | 乙醇 |
GHS
相关法规
运输信息
| HS编码* | 2932.20-000 |
应用
Eplerenone: A Selective Mineralocorticoid Receptor Antagonist
Eplerenone is a mineralocorticoid receptor antagonist. It binds to the receptor and locks the binding of aldosterone, a component of the renin-angiotensin-aldosterone-system (RAAS). Aldosterone binds to mineralocorticoid receptors in tissues, and increases blood pressure through induction of sodium reabsorption and possibly other mechanisms. Eplerenone works by blocking the actions of aldosterone, and resulting in decreasing blood pressure. It is similar to spironolactone [S0260], though it is much more selective for the receptor in comparison. (The product is for research purpose only.)
References
- Three new epoxy-spirolactone derivatives: characterization in vivo and in vitro
- Aldosterone/salt induces renal inflammation and fibrosis in hypertensive rats
- Effects of Long-Term Monotherapy With Eplerenone, a Novel Aldosterone Blocker, on Progression of Left Ventricular Dysfunction and Remodeling in Dogs With Heart Failure
- Cardioprotective mechanisms of eplerenone on cardiac performance and remodeling in failing rat hearts
- Molecular mechanisms of mineralocorticoid receptor antagonism by eplerenone (a review)
- A validated SPE-LC-MS/MS assay for Eplerenone and its hydrolyzed metabolite in human urine
- Stability-indicating RP-HPLC method for analysis of eplerenone in the bulk drug and in a pharmaceutical dosage form
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