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CAS RN: 209216-23-9 | 产品编码: E0899
Entecavir Monohydrate
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This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| 产品编码 | E0899 |
| 纯度/分析方法 | >98.0%(T)(HPLC) |
| 分子式/分子量 | C__1__2H__1__5N__5O__3·H__2O = 295.30 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| 包装和容器 | 200MG-Glass Bottle with Plastic Insert （查看图片）, 50MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 209216-23-9 |
| 相关CAS RN | 142217-69-4 |
| Reaxys-RN | 14632881 |
| PubChem物质ID | 253660820 |
| Merck Index (14) | 3595 |
| MDL编号 | MFCD09754448 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Specific rotation [a]20/D | +34.0 to +38.0 deg(C=0.25, H2O)(calcd.on anh.substance) |
| Water | 4.0 to 9.0 % |
物性（参考值）
| 熔点 | 259 °C(dec.) |
| 比旋光度 [α]D | 36° (C=0.25,H2O) |
| 在水中的溶解度 | 2.4 g/l |
| 溶解性（可溶于） | 二甲基甲酰胺 |
| 溶解性（微溶于） | 甲醇 |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H302 : Harmful if swallowed. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相关法规
运输信息
| HS编码* | 2933.99-000 |
应用
Cefdinir: A Third-Generation Cephalosporin More Active Against Gram-Positive Organisms
Entecavir (ETV or BMS-200475), a deoxyguanosine analog, is rapidly phosphorylated in vivo to the active intracellular 5'-triphosphate form that inhibits replication of hepatitis B virus (HBV) and shows reduced activity against other viruses, including HIV-1, influenza and herpes simplex viruses. Entecavir is a nucleoside reverse transcriptase inhibitor (NRTI). It inhibits reverse transcription in the viral replication process. (The product is for research purpose only.)
References
- BMS-200475, a novel carbocyclic 2'-deoxyguanosine analog with potent and selective anti-hepatitis B virus activity in vitro
- Metabolic studies on BMS-200475, a new antiviral compound active against hepatitis B virus
- Efficacies of entecavir against lamivudine-resistant hepatitis B virus replication and recombinant polymerases in vitro
- Potent efficacy of entecavir (BMS-200475) in a Duck model of hepatitis B virus replication
- Inhibition of hepatitis B virus polymerase by entecavir
- Entecavir: A review of its use in chronic hepatitis B
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