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CAS RN: 127783-34-0 | 产品编码: E0467
Ethynyl(phenyl)iodonium Tetrafluoroborate [Ethynylating Reagent]
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![Ethynyl(phenyl)iodonium Tetrafluoroborate [Ethynylating Reagent]](/_ui/responsive/theme-tci/images/missing_product_zoom.jpg "Ethynyl(phenyl)iodonium Tetrafluoroborate [Ethynylating Reagent]")
技术规格
| Appearance | White to Yellow to Orange powder to crystal |
| Purity( Potassium iodate Method) | min. 97.0 % |
物性（参考值）
GHS
| 象形图 |
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| 信号词 | Danger |
| 危险性说明 | H302 : Harmful if swallowed. H314 : Causes severe skin burns and eye damage. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dusts or mists. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P303 + P361 + P353 : IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower. P301 + P330 + P331 : IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P363 : Wash contaminated clothing before reuse. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor. P305 + P351 + P338 + P310 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor. P405 : Store locked up. |
相关法规
运输信息
| UN编号 | UN1759 |
| 类别 | 8 |
| 包装类别 | III |
| HS编码* | 2942.00-000 |
应用
Ethynylation of 1,3-Dicarbonyl Compounds
Typical Procedure:
A solution of 1,3-dicarbonyl compound (76 mg, 0.40 mmol) and NaH (11 mg, 0.48 mmol) in THF (2 mL) is stirred at rt for 1 h under an atmosphere of nitrogen. Ethynyl(phenyl)iodonium tetrafluoroborate1) (150 mg, 0.48 mmol) is then added and the resulting mixture is stirred at rt for 3 h. The reaction mixture is diluted with H2O (5 mL) and extracted with Et2O (3 x 10 mL). The combined organic layers are dried over MgSO4 and the solvent is removed under reduced pressure. The crude product is purified by silica gel flash chromatography (Hexane : EtOAc = 20 : 1) to afford the ethynylated compound (59 mg, 69%) as yellow solid.
A solution of 1,3-dicarbonyl compound (76 mg, 0.40 mmol) and NaH (11 mg, 0.48 mmol) in THF (2 mL) is stirred at rt for 1 h under an atmosphere of nitrogen. Ethynyl(phenyl)iodonium tetrafluoroborate1) (150 mg, 0.48 mmol) is then added and the resulting mixture is stirred at rt for 3 h. The reaction mixture is diluted with H2O (5 mL) and extracted with Et2O (3 x 10 mL). The combined organic layers are dried over MgSO4 and the solvent is removed under reduced pressure. The crude product is purified by silica gel flash chromatography (Hexane : EtOAc = 20 : 1) to afford the ethynylated compound (59 mg, 69%) as yellow solid.
References
- 1)Synthesis of ethynyl(phenyl)iodonium tetrafluoroborate. A new reagent for ethynylation of 1,3-dicarbonyl compounds
- 2)Ethynyl-1,2-benziodoxol-3(1H)-one (EBX): An Exceptional Reagent for the Ethynylation of Keto, Cyano, and Nitro Esters
参考文献