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CAS RN: 562-10-7 | 产品编码: D5583
Doxylamine Succinate
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| 产品编码 | D5583 |
| 纯度/分析方法 | >98.0%(T)(HPLC) |
| 分子式/分子量 | C__1__7H__2__2N__2O·C__4H__6O__4 = 388.46 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷冻 (<0°C) |
| 应避免的情况 | 光,加热 |
| CAS RN | 562-10-7 |
| 相关CAS RN | 469-21-6 |
| PubChem物质ID | 468591428 |
| Merck Index (14) | 3441 |
| MDL编号 | MFCD00056168 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 %(total of Ion-Pair) |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 109.0 to 113.0 °C |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 111 °C |
| 溶解性（可溶于） | 醇, 氯仿 |
| 溶解性（微溶于） | 苯, 乙醚 |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H302 : Harmful if swallowed. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相关法规
| RTECS# | US9275000 |
运输信息
| HS编码* | 2933.39-000 |
应用
Doxylamine Succinate: A First-Generation Anti-Histamine
Doxylamine succinate is a first-generation anti-histamine similar in structure to diphenhydramine [D4744]. Because of its sedative effect, it is often used for the treatment of insomnia and nausea in clinical use. (The product is for research purpose only.)
References
- Doxylamine succinate-pyridoxine hydrochloride (Diclegis) for the management of nausea and vomiting in pregnancy: an overview (a review)
- Simultaneous determination of pyridoxine hydrochloride and doxylamine succinate from tablets by ion pair reversed-phase high-performance liquid chromatography (RP-HPLC)
- Determination of the sleep aid ingredients diphenhydramine hydrochloride and doxylamine succinate in pharmaceutical products by quantitative HPTLC
- Simultaneous determination of dextromethorphan, dextrorphan and doxylamine in human plasma by HPLC coupled to electrospray ionization tandem mass spectrometry: Application to a pharmacokinetic study
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