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CAS RN: 54573-75-0 | 产品编码: D5526
Doxercalciferol
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技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Specific rotation [a]20/D | +46.0 to +50.0 deg(C=0.5,EtOH) |
| Elemental analysis(Carbon) | 79.90 to 83.10 % |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 140 °C |
| 最大吸收波长 | 265(EtOH) nm |
GHS
| 象形图 |
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| 信号词 | Danger |
| 危险性说明 | H300 : Fatal if swallowed. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
相关法规
| RTECS# | VS2950000 |
运输信息
| UN编号 | UN2811 |
| 类别 | 6.1 |
| 包装类别 | I |
| HS编码* | 2936.29-000 |
应用
Doxercalciferol: A Prodrug of 1α,25-Dihydroxyvitamin D2, an Active Form of Vitamin D2
Doxercalciferol (other name: 1α-hydroxyvitamin D2), a synthetic vitamin D2 analog, was first synthesized from ergosterol [E0018].1) It is a prodrug requiring hepatic metabolism to the active metabolite 1α,25-dihydroxyvitamin D2 (1α, 25-(OH)2D2), a biologically active form of vitamin D2.2) The active vitamin D2 binds the vitamin D receptor (VDR) to result in the selective activation of vitamin D responsive pathway. It has been reported that doxercalciferol reduces parathyroid hormone (PTH) levels by inhibiting PTH synthesis and secretion.3) In clinical, doxercalciferol is used for the treatment of secondary hyperparathyroidism (2HPT) and metabolic bone disease.3,4) (The product is for research purpose only.)
References
- 1) Synthesis of 1α-hydroxyergocalciferol
- 2) 1α,24(S)-dihydroxyvitamin D: a biologically active product of 1α-hydroxyvitamin D made in the human hepatoma, Hep3B
- 3) Vitamin D analogues for secondary hyperparathyroidism
- 4) Doxercalciferol treatment of secondary hyperparathyroidism (a review)
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