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CAS RN: 1431-39-6 | 产品编码: D5405
Dansylamide [for Albumin binding assay]
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![Dansylamide [for Albumin binding assay]](/_ui/responsive/theme-tci/images/missing_product_zoom.jpg "Dansylamide [for Albumin binding assay]")
| 产品编码 | D5405 |
| 纯度/分析方法 | >98.0%(T) |
| 分子式/分子量 | C__1__2H__1__4N__2O__2S = 250.32 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| 应避免的情况 | 光 |
| 包装和容器 | 100MG-Glass Bottle with Plastic Insert （查看图片）, 25MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 1431-39-6 |
| Reaxys-RN | 2217203 |
| PubChem物质ID | 354335223 |
| SDBS (AIST Spectral DB) | 11148 |
| MDL编号 | MFCD00004000 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 218.0 to 222.0 °C |
| Human serum albmin (HSA) binding activity | S/N ratio min. 4 |
| Competitive avtivity in competitive drug | Remaining fluorescein inensity max. 70 % |
| Non-competitive avtivity in non-competitive drug | Remaining fluoresein intensity min. 80 % |
物性（参考值）
| 熔点 | 219 °C |
| 溶解性（可溶于） | 二甲基甲酰胺 |
GHS
相关法规
运输信息
| HS编码* | 2935.90-000 |
应用
Fluorescent Probes for the Characterization of Two Specific Drug Binding Sites on HSA
Human Serum Albumin (HSA) binds to a wide variety of drugs at two primary binding sites (I: blue and II: yellow), and can have a significant impact on their pharmacokinetics and pharmacological effects. The fluorescent probes, dansylamide (1) and dansylglycine (2) selectively interact with sites I and II, respectively.1,2) BD140 (3) also binds to drug binding site II specifically.3) Changes in probe fluorescence are analyzed by fluorescence titrations as a result of competitive displacient by drugs and pharmaceuticals. The pattern of fluorescent probe displacient by these reagents enabled the identification of two specific drug binding sites, which illustrates their usefulness for the characterization of the binding sites in HSA.
References
- 1)The Characterization of Two Specific Drug Binding Sites on Human Serum Albumin
- 2)Further Characterization of Specific Drug Binding Sites on Human Serum Albumin
- 3)Fluorescent Dye Cocktail for Multiplex Drug-Site Mapping on Human Serum Albumin
应用
Specific fluorescent probe binding to drug binding site 1 on human serum albumin (HSA)
References
- Drug binding properties of glycosylated human serum albumin as measured by fluorescence and circular dichroism
- A general, wide-rage spectrofluorometric method for measuring the site-specific affinities of drugs toward human serum albumin
- Structural and functional insights into S-thiolation of human serum albumins
- Binding modes of environmental endocrine disruptors to human serum albumin: insights from STD-NMR, ITC, spectroscopic and molecular docking studies
- 8‐Prenylnaringenin tissue distribution and pharmacokinetics in mice and its binding to human serum albumin and cellular uptake in human embryonic kidney cells
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![Dansylamide [for Fluorometry]](/medias/D1507.jpg?context=bWFzdGVyfHJvb3R8Mjc3MjN8aW1hZ2UvanBlZ3xhRGd3TDJnNU55ODVNVGN6T1RZNU5EWTVORGN3TDBReE5UQTNMbXB3Wnd8Yzk1MDNmYmNhZjdjMzJjYTEyNmRlYTk5OWNiMjg0M2RmM2Q1MzNhZmQ4NDRlMjczZjRhNTUxODI1MTYwOTcxYg "Dansylamide [for Fluorometry]")