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CAS RN: 364622-82-2 | 产品编码: D5249
Doripenem Monohydrate
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| 产品编码 | D5249 |
| 纯度/分析方法 | >98.0%(HPLC) |
| 分子式/分子量 | C__1__5H__2__4N__4O__6S__2·H__2O = 438.52 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷藏 (0-10°C) |
| 应避免的情况 | 加热 |
| 包装和容器 | 250MG-Glass Bottle with Plastic Insert （查看图片）, 50MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 364622-82-2 |
| 相关CAS RN | 148016-81-3 |
| Reaxys-RN | 15340136 |
| PubChem物质ID | 354335134 |
| MDL编号 | MFCD09749887 |
技术规格
| Appearance | White to Light yellow to Light orange powder to crystal |
| Specific rotation [a]20/D | +32.0 to +37.0 deg(C=1, H2O) |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 12.00 to 13.50 % |
物性（参考值）
| 熔点 | 173 °C(dec.) |
| 比旋光度 [α]D | 34° (C=1,H2O) |
GHS
相关法规
运输信息
| HS编码* | 2935.90-000 |
应用
Doripenem: A Carbapenem Antibiotic with Broad-Spectrum Activity
Doripenem (S-4661) is a carbapenem antibiotic with broad-spectrum activity against Gram-negative and Gram-positive bacteria, including multidrug-resistant strains and Pseudomonad aeruginosa. Carbapenems, including doripenem, act fungicidally by inhibiting bacterial cell wall biosynthesis by binding to and inactivating penicillin-binding proteins (PBPs) which are essential enzymes for the biosynthesis. In addition, carbapenems are stable to most β-lactamases including AmpC β-lactamases and extended-spectrum β-lactamases. (The product is for research purpose only.)
References
- Doripenem versus Pseudomonas aeruginosa in vitro: Activity against characterized isolates, mutants, and transconjugants and resistance selection potential
- Comparative activity of doripenem and three other carbapenems tested against Gram-negative bacilli with various ＆beta;-lactamase resistance mechanisms
- Doripenem (a review)
- Comparative review of the carbapenems
- Quantification of doripenem in human plasma and peritoneal fluid by high-performance liquid chromatography with ultraviolet detection
- Characterization of the antibiotic doripenem using physicochemical methods - chromatography, spectrophotometry, spectroscopy and thermal analysis
- Stability-indicating RP-HPLC method for analysis of the antibiotic doripenem in pharmaceutical formulation -Comparison to UV spectrophotometry and microbiological assay
参考文献
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