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CAS RN: 23541-50-6 | 产品编码: D4532
Daunorubicin Hydrochloride
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| 产品编码 | D4532 |
| 纯度/分析方法 | >98.0%(N) |
| 分子式/分子量 | C__2__7H__2__9NO__1__0·HCl = 563.98 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷藏 (0-10°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 湿气 (吸湿),加热 |
| 包装和容器 | 100MG-Glass Bottle with Plastic Insert （查看图片）, 20MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 23541-50-6 |
| 相关CAS RN | 20830-81-3 |
| Reaxys-RN | 4229221 |
| PubChem物质ID | 253661912 |
| Merck Index (14) | 2832 |
| MDL编号 | MFCD04974507 |
技术规格
| Appearance | Orange to Red powder to crystal |
| Purity(HPLC) | min. 96.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 %(calcd.on dried substance) |
| Specific rotation [a]20/D | +250 to +275 deg(C=0.15, MeOH) |
| Drying loss | max. 7.5 % |
物性（参考值）
| 熔点 | 167 °C(dec.) |
| 比旋光度 [α]D | 260° (C=0.15,MeOH) |
| 最大吸收波长 | 477 nm (H__2O) |
| 水溶性 | 可溶 |
| 溶解性（可溶于） | 甲醇 |
| 溶解性（不溶于） | 乙醚, 苯, 氯仿 |
GHS
| 象形图 |
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| 信号词 | Danger |
| 危险性说明 | H301 : Toxic if swallowed. H317 : May cause an allergic skin reaction. H334 : May cause allergy or asthma symptoms or breathing difficulties if inhaled. H341 : Suspected of causing genetic defects. H351 : Suspected of causing cancer. H413 : May cause long lasting harmful effects to aquatic life. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust. P273 : Avoid release to the environment. P272 : Contaminated work clothing should not be allowed out of the workplace. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P284 : Wear respiratory protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P342 + P311 : If experiencing respiratory symptoms: Call a POISON CENTER/doctor. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P362 + P364 : Take off contaminated clothing and wash it before reuse. P304 + P340 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
相关法规
| RTECS# | HB7878000 |
运输信息
| UN编号 | UN2811 |
| 类别 | 6.1 |
| 包装类别 | III |
| HS编码* | 2941.90-000 |
应用
Adeno-associated virus vector transduction enhancer
Daunorubicin exhibits enhancement of adeno-associated virus transduction.1)
References
- 1) Identification and validation of small molecules that enhance recombinant adeno-associated virus transduction following high-throughput screens
应用
Daunorubicin Hydrochloride: An Anthracycline Antitumor Antibiotic
Daunorubicin Hydrochloride, an anthracycline antitumor antibiotic, was first isolated from fermentation broths of Streptomyces peucetius in 1967. Daunorubicin interacts with DNA by intercalation that causes disruption of transcription and replication. Daunorubicin also forms a complex with DNA and the enzyme topoisomerase II which is essential enzyme for DNA replication. The complexation hinders religation and leads to tumor cell apoptosis. Daunorubicin is mainly used for acute myeloid leukemia. (The product is for research purpose only.)
References
- Ceramide synthase mediates daunorubicin-induced apoptosis: an alternative mechanism for generating death signals
- Biosynthetic studies of daunorubicin and tetracenomycin C (a review)
- A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics Adriamycin and daunorubicin (a review)
- Anthracyclines: Molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity (a review)
- DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs (a review)
参考文献
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