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CAS RN: 13739-02-1 | 产品编码: D4061
Diacerein
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| 产品编码 | D4061 |
| 纯度/分析方法 | >98.0%(HPLC) |
| 分子式/分子量 | C__1__9H__1__2O__8 = 368.30 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 13739-02-1 |
| Reaxys-RN | 2184909 |
| PubChem物质ID | 135727331 |
| SDBS (AIST Spectral DB) | 53256 |
| Merck Index (14) | 2960 |
| MDL编号 | MFCD00468030 |
技术规格
| Appearance | Light yellow to Amber to Dark green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(qNMR) | min. 97.0 % |
| Melting point | 241.0 to 245.0 °C |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 243 °C |
GHS
| 象形图 |
|
| 信号词 | Warning |
| 危险性说明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防范说明 | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
相关法规
| RTECS# | CB8781000 |
运输信息
| HS编码* | 2918.99-000 |
应用
Bone research
References
- Diacerein inhibits the synthesis of resorptive enzymes and reduces osteoclastic differentiation/survival in osteoarthritic subchondral bone: a possible mechanism for a protective effect against subchondral bone remodelling
- Diacerhein and rhein reduce the ICE-induced IL-1β and IL-18 activation in human osteoarthritic cartilage
应用
Studies on Anti-inflammatory Effect
References
- Diacerhein and rhein reduce the interleukin 1β stimulated inducible nitric oxide synthesis level and activity while stimulating cyclooxygenase-2 synthesis in human osteoarthritic chondrocytes
- J.-P. Pelletier, F. Mineau, J. C. Fernandes, N. Duval, J. Martel-Pelletier, J. Heumatology 1998, 25, 2417.
- Diacerein
- Pharmacological studies of diacerein in animal models of inflammation, arthritis and bone resorption
参考文献
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技术规格
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