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CAS RN: 224311-51-7 | 产品编码: D3387
2-(Di-tert-butylphosphino)biphenyl
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This product is intended for research and development purposes only. It may not be used for (i) any human or veterinary use, including without limitation therapeutic and prophylactic use, (ii) any clinical use, including without limitation diagnostic use. Any use of this product for any of the above mentioned purposes requires a license from the Massachusetts Institute of Technology.
List of Patent Applications and Patents (PDF)
| 产品编码 | D3387 |
| 纯度/分析方法 | >98.0%(GC) |
| 分子式/分子量 | C__2__0H__2__7P = 298.41 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 224311-51-7 |
| Reaxys-RN | 8322131 |
| PubChem物质ID | 87558786 |
| MDL编号 | MFCD01862440 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(GC) | min. 98.0 % |
| Melting point | 85.0 to 89.0 °C |
物性（参考值）
| 熔点 | 87 °C |
| 水溶性 | 不溶 |
| 溶解性（可溶于） | 甲苯 |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. H413 : May cause long lasting harmful effects to aquatic life. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
相关法规
运输信息
| HS编码* | 2931.49-900 |
应用
TCI Practical Example: Buchwald-Hartwig Amination Using JohnPhos
Used Chemicals
Procedure
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To a solution of sodium tert-butoxide (0.54 g, 5.6 mmol), palladium(II) acetate (4.5 mg, 0.020 mmol), and JohnPhos (0.012 g, 0.040 mmol) in toluene (8 mL) 4-chlorotoluene (0.51 g, 4.0 mmol) and morpholine (0.42 g, 4.8 mmol) were successively added at room temperature. The mixture was stirred under nitrogen atmosphere at room temperature for 1.5 days, then under reflux condition for 0.5 days. Diethyl ether (20 mL) was added to the reaction mixture and filtered through celite. Solvent was removed and the residue was purified by column chromatography (1:4 ethyl acetate / hexane on SiO2), giving 4-(p-tolyl)morpholine as a pale brown solid (0.45 g, 63% yield).
Experimenter's Comments
The reaction mixture was monitored by 1H NMR.
Analytical Data (4-(p-Tolyl)morpholine)
1H NMR (400 MHz, CDCl3); δ 7.10 (d, J = 8.2 Hz, 2H), 6.85 (d, J = 8.2 Hz, 2H), 3.87 (t, J = 4.6 Hz, 4H), 3.12 (t, J = 4.8 Hz, 4H), 2.28 (s, 3H).
13C NMR (101 MHz, CDCl3); δ 129.9 (4 C), 116.2 (2 C), 67.1 (2 C), 50.1 (2 C), 20.6.
Lead Reference
- A Highly Active Catalyst for the Room-Temperature Amination and Suzuki Coupling of Aryl Chlorides
Other References
- Simple, Efficient Catalyst System for the Palladium-Catalyzed Amination of Aryl Chlorides, Bromides, and Triflates
应用
Fluorination of Alkynes using an Stable HF Complex : DMPU-HF and Gold Catalyst
Reference
- Designer HF-Based Fluorination Reagent: Highly Regioselective Synthesis of Fluoroalkenes and gem-Difluoromethylene Compounds from Alkynes
应用
Vinylation of aryl bromides
Reference
参考文献
文章/手册
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