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CAS RN: 138977-28-3 | 产品编码: C3923
Capsazepine
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纯度/分析方法: >98.0%(HPLC)(qNMR)
别名：
- 辣椒平
- N-(4-氯苯基乙基)-7,8-二羟基-1,3,4,5-四氢-2H-苯并[c]氮杂卓-2-硫代甲酰胺
- N-[2-(4-氯苯基)乙基]-7,8-二羟基-1,3,4,5-四氢-2H-2-苯并氮杂卓-2-硫代甲酰胺
- N-(4-Chlorophenethyl)-7,8-dihydroxy-1,3,4,5-tetrahydro-2H-benzo[c]azepine-2-carbothioamide
- N-[2-(4-Chlorophenyl)ethyl]-7,8-dihydroxy-1,3,4,5-tetrahydro-2H-2-benzazepine-2-carbothioamide
产品文档：
| 规格 | 单价 | 同一天 | 2-3个工作日 | 左侧以上货期 | 数量 |
货期信息
|
|---|---|---|---|---|---|---|
| 10MG |
S$219.00
|
5 | 2 | 下单后约3-4周内可以发货 |
|
| 产品编码 | C3923 |
| 纯度/分析方法 | >98.0%(HPLC)(qNMR) |
| 分子式/分子量 | C__1__9H__2__1ClN__2O__2S = 376.90 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷藏 (0-10°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 空气,加热 |
| CAS RN | 138977-28-3 |
| Reaxys-RN | 7047754 |
| MDL编号 | MFCD00153778 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(qNMR) | min. 98.0 % |
| Melting point | 157.0 to 161.0 °C |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 159 °C |
| 溶解性（可溶于） | 乙醇 |
GHS
相关法规
| RTECS# | CX7075000 |
运输信息
| HS编码* | 2933.99-000 |
应用
Capsazepine: A Competitive Antagonist of TRPV1
Capsazepine is a synthetic analog of capsaicin [M1149] [M0900] that can act as a competitive antagonist of transient receptor potential vanilloid 1 (TRPV1), a non-selective cation channel that can be activated by a variety of exogenous and endogenous physical and chemical stimuli.1-3) Recently, capsazepine has been reported to exhibit pleiotropic anticancer effects as an apoptosis inducer against numerous tumor cell lines.4) (The product is for research purpose only.)
References
- 1) Capsazepine: a competitive antagonist of the sensory neuron excitant capsaicin
- 2) Capsazepine block of voltage-activated calcium channels in adult rat dorsal root ganglion neurons in culture
- 3) The VR1 antagonist capsazepine reverses mechanical hyperalgesia in models of inflammatory and neuropathic pain
- 4) Pleiotropic pharmacological actions of capsazepine, a synthetic analogue of capsaicin, against various cancers and inflammatory diseases (a review)
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