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CAS RN: 163252-36-6 | 产品编码: C3845
Clevudine
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纯度/分析方法: >98.0%(T)(HPLC)
别名：
- 克拉夫定
- 1-(2-脱氧-2-氟-β-L-阿拉伯呋喃糖基)-5-甲基-2,4(1H,3H)-嘧啶二酮
- 1-[(2S,3R,4S,5S)-3-氟-4-羟基-5-(羟甲基)四氢呋喃-2-基]-5-甲基嘧啶-2,4(1H,3H)-二酮
- 1-(2-Deoxy-2-fluoro-β-L-arabinofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione
- 1-[(2S,3R,4S,5S)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
产品文档：
| 产品编码 | C3845 |
| 纯度/分析方法 | >98.0%(T)(HPLC) |
| 分子式/分子量 | C__1__0H__1__3FN__2O__5 = 260.22 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷藏 (0-10°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 空气,加热 |
| 包装和容器 | 250MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 163252-36-6 |
| Reaxys-RN | 8153334 |
| MDL编号 | MFCD00935785 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Volumetric Analysis) | min. 98.0 % |
| Melting point | 193.0 to 197.0 °C |
| Specific rotation | -107 to -117 deg(C=0.2, methanol) |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 196 °C |
GHS
相关法规
| RTECS# | UV9052000 |
运输信息
| HS编码* | 2934.99-000 |
应用
Clevudine: An L-Configuration Thymidine Analog with Antiviral Activity
Clevudine (L-FMAU; 2'-fluoro-5-methyl-β-L-arabinofuranosyluracil) is an unnatural L-configuration thymidine analog with potent anti-hepatitis B virus (HBV) activity in vitro and in vivo. There are reports that clevudine interferes with HBV replication by inhibiting the activity of viral DNA polymerase and reverse transcriptase. (The product is for research purpose only.)
References
- Use of 2'-fluoro-5-methyl-β-L-arabinofuranosyluracil as a novel antiviral agent for hepatitis B virus and Epstein-Barr virus
- Preclinical investigation of L-FMAU as an anti-hepatitis B virus agent (a review)
- Inhibitory effect of 2'-fluoro-5-methyl-beta-L-arabinofuranosyl-uracil on duck hepatitis B virus replication
- Clevudine: a potent inhibitor of hepatitis B virus in vitro and in vivo (a review)
- Nucleoside/nucleotide analog inhibitors of hepatitis B virus polymerase: mechanism of action and resistance (a review)
- Hepatitis B virus reverse transcriptase - Target of current antiviral therapy and future drug development (a review)
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技术规格
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