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CAS RN: 126544-47-6 | 产品编码: C3701
Ciclesonide
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纯度/分析方法: >98.0%(HPLC)
别名：
- 环索奈德
- 2-[(6aR,6bS,7S,8aS,8bS,10R,11aR,12aS,12bS)-10-环己基-7-羟基-6a,8a-二甲基-4-氧代-1,2,4,6a,6b,7,8,8a,11a,12,12a,12b-十二氢-8bH-萘并[2',1':4,5]茚并[1,2-d][1,3]二氧戊环-8b-基]-2-氧代乙基异丁酸酯
- 2-[(6aR,6bS,7S,8aS,8bS,10R,11aR,12aS,12bS)-10-Cyclohexyl-7-hydroxy-6a,8a-dimethyl-4-oxo-1,2,4,6a,6b,7,8,8a,11a,12,12a,12b-dodecahydro-8bH-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-8b-yl]-2-oxoethyl Isobutyrate
产品文档：
补充产品信息:
This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 207.0 to 211.0 °C |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 209 °C |
| 水溶性 | 不溶 |
| 溶解性（可溶于） | 乙醇, 二甲基甲酰胺, 甲醇, 丙酮 |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H361 : Suspected of damaging fertility or the unborn child. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
相关法规
运输信息
| HS编码* | 2937.29-000 |
应用
Ciclesonide: An Inhaled Glucocorticoid with Anti-Inflammatory Activity
Ciclesonide, is an inhaled prodrug, which is enzymatically hydrolyzed to a pharmacologically active metabolite, desisobutyryl-ciclesonide following oral inhalation.1-3) The active metabolite has anti-inflammatory activity with affinity for glucocorticoid receptors of the airway that is 120 times greater than the parent compound and 12 times greater than dexamethasone [D1962].4) Ciclesonide is used for the treatment of asthma. In 2020, it has been reported that ciclesonide blocks coronavirus (SARS-CoV-2) RNA replication.5) For your reference, the solubility of ciclesonide in organic solvents has been reported.6) (The product is for research purpose only.)
References
- 1) In vitro and in vivo anti-inflammatory activity of the new glucocorticoid ciclesonide
- 2) Ciclesonide (a review)
- 3) Sensitive simultaneous determination of ciclesonide, ciclesonide-M1-metabolite and fluticasone propionate in human serum by HPLC-MS/MS with APPI
- 4) Pharmaceutical Approval Update: Ciclesonide (Alvesco) Inhalation Aerosol
- 5) The inhaled corticosteroid ciclesonide blocks coronavirus RNA replication by targeting viral NSP15
- 6) Measurement and correlation of solubility of ciclesonide in seven pure organic solvents
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