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CAS RN: 6001-74-7 | 产品编码: C3020
Chlormethiazole Hydrochloride
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| 产品编码 | C3020 |
| 纯度/分析方法 | >98.0%(T)(HPLC) |
| 分子式/分子量 | C__6H__8ClNS·HCl = 198.11 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 湿气 (吸湿) |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片）, 200MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 6001-74-7 |
| 相关CAS RN | 533-45-9 |
| Reaxys-RN | 3697289 |
| PubChem物质ID | 253662385 |
| Merck Index (14) | 2384 |
| MDL编号 | MFCD00673948 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 134.0 to 138.0 °C |
物性（参考值）
| 熔点 | 136 °C |
| 水溶性 | 可溶 |
| 溶解性（可溶于） | 醇 |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防范说明 | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
相关法规
运输信息
| HS编码* | 2934.10-000 |
应用
Chlormethiazole Hydrochloride: A Neuroprotective and a CYP2E1 Inhibitory Agent
Chlormethiazole hydrochloride is a thiazole derivative with sedative and anticonvulsive properties. The mechanism of action is considered to involve the potentiation of GABA [A0282] activity, the major intrinsic inhibitory neurotransmitter. Chlormethiazole is also reported to inhibit cytochrome P 450 2E (CYP2E1) which is suggested to alcoholic liver disease. (The product is for research purpose only.)
References
- Neuroprotective activity of chlormethiazole following transient forebrain ischemia in the gerbil
- The pharmacology of chlormethiazole: a potential neuroprotective agent? (A review)
- Chlormethiazole as an efficient inhibitor of cytochrome P450 2E1 expression in rat liver
- nhibition of ethanol-induced liver disease in the intragastric feeding rat model by chlormethiazole
参考文献
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