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CAS RN: 117467-28-4 | 产品编码: C2856
Cefditoren Pivoxil
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This product has not been tested for potency and is guaranteed for chemical purity.
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Specific rotation [a]20/D | -45.0 to -52.0 deg(C=0.5, MeOH) |
| Water | max. 1.5 % |
物性（参考值）
| 熔点 | 209 °C(dec.) |
| 比旋光度 [α]D | -48.5° (C=0.5,MeOH) |
| 水溶性 | 不溶 |
| 溶解性（微溶于） | 甲醇 |
| 溶解性（不溶于） | 乙醚 |
GHS
相关法规
| RTECS# | XI0367800 |
运输信息
| HS编码* | 2941.90-000 |
应用
Cefditoren pivoxil: A Third-Generation Cephalosporin with Antibacterial Effects against PRSP and BLNAR
Cefditoren pivoxil is a prodrug of the third-generation cephalosporin that is rapidly hydrolyzed by intestinal esterases to the microbiologically active cephalosporin cefditoren. Cefditoren has broad spectrum of activity against Gram-positive and Gram-negative bacteria, including common respiratory and skin pathogens. Cefditoren has potent antibacterial effects against penicillin-resistant Streptococcus pneumoniae (PRSP) and β-lactamase-non-producing-ampicillin resistant (BLNAR) Haemophilus influenzae among the oral β-lactam antibiotics. However, cefditoren does not have antibacterial activity against Pseudomonas aeruginosa.For your reference, [M2411] is a synthetic intermediates of cefditoren pivoxil. (The product is for research purpose only.)
References
- Antimicrobial activity and in vitro susceptibility test development for cefditoren against Haemophilus influenzae, Moraxella catarrhalis, and Streptococcus species
- Crystal structure of cefditoren complexed with Streptococcus pneumoniae penicillin-binding protein 2X: structural basis for its high antimicrobial activity
- Cefditoren pivoxil (a review)
- Cefditoren pivoxil: A review of its use in the treatment of bacterial infections
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