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CAS RN: 52214-84-3 | 产品编码: C2667
| 产品编码 | C2667 |
| 纯度/分析方法 | >98.0%(GC)(T) |
| 分子式/分子量 | C__1__3H__1__4Cl__2O__3 = 289.15 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷藏 (0-10°C) |
| 应避免的情况 | 加热 |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 52214-84-3 |
| Reaxys-RN | 1984981 |
| PubChem物质ID | 160871346 |
| Merck Index (14) | 2313 |
| MDL编号 | MFCD00467135 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(GC) | min. 98.0 % |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 116.0 to 120.0 °C |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 118 °C |
| 溶解性（可溶于） | 甲醇 |
GHS
相关法规
| RTECS# | UF0880000 |
运输信息
| HS编码* | 2918.99-000 |
应用
Clofibrate: Antilipemic with Activity against Peroxisome Proliferator-Activated Receptors (PPARs)
The fibrates, including ciprofibrate, are lower elevated serum lipids by decreasing the low density lipoprotein (LDL) fraction rich in cholesterol and the very low density lipoprotein (VLDL) fraction rich in triglycerides. In addition, fibrates increase the high density lipoprotein (HDL) cholesterol fraction. The precise mechanisms of action remain unknown, but it has been reported that the major modes of action of the fibrates as follows: VLDL catabolism by increased lipoprotein and hepatic triglyceride lipase activities; suppression of triglyceride biosynthesis by acetyl-CoA carboxylase enzyme inhibition and attenuation of cholesterol biosynthesis by inhibition of the rate-limiting HMG-CoA reductase.
Since the late 1990s, it has been reported that fibrates activate specific transcription factors belonging to the nuclear hormone receptor superfamily, termed peroxisome proliferator-activated receptors (PPARs) which activation increases HDL cholesterol synthesis, stimulates "reverse" cholesterol transport and reduces triglycerides. (The product is for research purpose only.)
Since the late 1990s, it has been reported that fibrates activate specific transcription factors belonging to the nuclear hormone receptor superfamily, termed peroxisome proliferator-activated receptors (PPARs) which activation increases HDL cholesterol synthesis, stimulates "reverse" cholesterol transport and reduces triglycerides. (The product is for research purpose only.)
References
- Mechanism of action of fibrates on lipid and lipoprotein metabolism (a review)
- The peroxisome proliferator-activated receptor α-selective activator ciprofibrate upregulates expression of genes encoding fatty acid oxidation and ketogenesis enzymes in rat brain
- Liver gene expression in rats in response to the peroxisome proliferator-activated receptor-α agonist ciprofibrate
- Determination of bezafibrate, ciprofibrate and fenofibric acid in human plasma by high-performance liquid chromatography
应用
Studies on Peroxisome Proliferator-Activated Receptors (PPARs)
References
- Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ
- Mechanism of action of fibrates on lipid and lipoprotein metabolism
- Peroxisome proliferator-activated receptor α activators improve insulin sensitivity and reduce adiposity
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