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CAS RN: 61422-45-5 | 产品编码: C2663
Carmofur

产品编码 | C2663 |
纯度/分析方法 | >98.0%(T)(HPLC) |
分子式/分子量 | C__1__1H__1__6FN__3O__3 = 257.27 |
外观与形状(20°C) | 固体 |
储存温度 | 冷藏 (0-10°C) |
应避免的情况 | 加热 |
包装和容器 | 1G-Glass Bottle with Plastic Insert (查看图片) |
CAS RN | 61422-45-5 |
Reaxys-RN | 888898 |
PubChem物质ID | 160871373 |
Merck Index (14) | 1844 |
MDL编号 | MFCD00866284 |
技术规格
Appearance | White to Almost white powder to crystal |
Purity(HPLC) | min. 98.0 area% |
Purity(Neutralization titration) | min. 98.0 % |
NMR | confirm to structure |
物性(参考值)
熔点 | 112 °C(dec.) |
水溶性 | 不溶 |
溶解性(可溶于) | 丙酮, 氯仿 |
溶解性(微溶于) | 乙醇, 甲醇 |
GHS
象形图 |
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信号词 | Danger |
危险性说明 | H301 : Toxic if swallowed. H361 : Suspected of damaging fertility or the unborn child. H373 : May cause damage to organs through prolonged or repeated exposure. |
防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
相关法规
RTECS# | UV7714000 |
运输信息
UN编号 | UN2811 |
类别 | 6.1 |
包装类别 | III |
HS编码* | 2933.59-000 |
应用
Carmofur (HCFU): 1-Hexylcarbamoyl Derivative of 5-FU
Carmofur (other name: HCFU) is an ester prodrug and metabolized by the action of CYP450 to form the active metabolite 5-FU [F0151].
References
- Antitumor activity of 1-hexylcarbamoyl-5-fluorouracil in a variety of experimental tumors
- Antitumor activity of 1-alkylcarbamoyl derivatives of 5-fluorouracil in a variety of mouse tumors
- Sensitivity of human KB cells expressing platelet-derived endothelial cell growth factor to pyrimidine antimetabolites
- Studies on the interaction between 1-hexylcarbamoyl-5-fluorouracil and bovine serum albumin
参考文献
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