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CAS RN: 50-63-5 | 产品编码: C2301
Chloroquine Diphosphate
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纯度/分析方法: >98.0%(T)(HPLC)
别名：
- 氯喹二磷酸盐
- N4-(7-氯-4-喹啉基)-N1,N1-二乙基-1,4-戊二胺二磷酸盐
- 7-氯-4-[4-(二乙氨基)-1-甲基丁氨基]喹啉二磷酸盐
- N4-(7-Chloro-4-quinolyl)-N1,N1-diethyl-1,4-pentanediamine Diphosphate
- 7-Chloro-4-[4-(diethylamino)-1-methylbutylamino]quinoline Diphosphate
产品文档：
补充产品信息:
This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
物性（参考值）
| 熔点 | 199 °C(dec.) |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H302 : Harmful if swallowed. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相关法规
| RTECS# | VB2450000 |
运输信息
| HS编码* | 2933.49-000 |
应用
Exosome research
References
- Interfering with endolysosomal trafficking enhances release of bioactive exosomes
应用
Chloroquine Diphosphate: A Derivative of 4-Aminoquinoline with Autophagy Inhibitory, Antimalarial and Anticancer Activities
Chloroquine diphosphate is a derivative of 4-aminoquinoline, which is an inhibitor of autophagy and has antimalarial and anticancer activities.1-3) In addition, chloroquine has been also reported to exert anti-corona viral activity, including anti-SARS-CoV-2, in vitro.4-6) The mechanism of action of chloroquine is not completely understood. But, some studies have demonstrated that chloroquine is a weak base and may exert its effect by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme. In addition, while chloroquine can inhibit certain enzymes, its effect is believed to result, at least in part from its interaction with DNA. (The product is for research purpose only.)
References
- 1) Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion
- 2) Antimalarial Agents: Chloroquine, Hydroxychloroquine, and Quinacrine (a review)
- 3) Chloroquine inhibits cell growth and induces cell death in A549 lung cancer cells
- 4) In vitro inhibition of severe acute respiratory syndrome coronavirus by chloroquine
- 5) Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro
- 6) Structural and molecular modelling studies reveal a new mechanism of action of chloroquine and hydroxychloroquine against SARS-CoV-2 infection
- 7) Chloroquine phosphate (a review on the physical properties, synthesis, metabolites, and methods of analysis)
- 8) Sensitive and rapid liquid chromatography/tandem mass spectrometric assay for the quantification of chloroquine in dog plasma
应用
Reagent for itching model
Reference
- Kappa opioid agonists suppress chloroquine-induced scratching in mice
参考文献
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