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CAS RN: 94790-35-9 | 产品编码: C1957
Chloro-N,N,N',N'-tetramethylformamidinium Hexafluorophosphate
产品编码 | C1957 |
纯度/分析方法 | >98.0%(N) |
分子式/分子量 | C__5H__1__2ClF__6N__2P = 280.58 |
外观与形状(20°C) | 固体 |
储存温度 | 冷冻 (<0°C) |
储存在惰性气体下 | 存放于惰性气体之中 |
应避免的情况 | 湿气 (分解),加热 |
包装和容器 | 1G-Glass Bottle with Plastic Insert (查看图片) |
CAS RN | 94790-35-9 |
Reaxys-RN | 7896715 |
PubChem物质ID | 87558395 |
技术规格
Appearance | White to Almost white powder to crystal |
Purity(with Total Nitrogen) | min. 98.0 % |
物性(参考值)
熔点 | 107 °C |
GHS
象形图 | |
信号词 | Warning |
危险性说明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
防范说明 | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
相关法规
运输信息
HS编码* | 2931.59-000 |
应用
A Condensation Reagent for Hindered Carboxylic Acids and Low-nucleophilic Amines
Experimental procedure: 2-Methyl-2-phenylpropanoic acid (0.250 g, 1.52 mmol), 4-aminobenzonitrile (0.234 g, 1.98 mmol) and N-methylimidazole (0.42 mL, 5.33 mmol) in acetonitrile are added with chloro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate (0.517 g, 1.83 mmol) in a single portion. After reaction, the reaction mixture is diluted with isopropyl acetate and water. The layers are separated, the aqueous layer is extracted with isopropyl acetate and the combined organics are washed with water, dried wover magnesium sulfate. The mixtute is filtered and concentrated, and then is purified by silica gel chromatography (heptane/isopropyl acetate) to give N-(4-cyanophenyl)-2-methyl-2-phenylpropanamide (374 mg, 93% yield) as a white solid.
References
- TCFH-NMI: Direct Access to N-Acyl Imidazoliums for Challenging Amide Bond Formations
应用
Active Esterification
Reference
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