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CAS RN: 866323-14-0 | 产品编码: B5888
Belinostat
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| 产品编码 | B5888 |
| 纯度/分析方法 | >98.0%(HPLC) |
| 分子式/分子量 | C__1__5H__1__4N__2O__4S = 318.35 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| 包装和容器 | 25MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 866323-14-0 |
| Reaxys-RN | 10087570 |
| PubChem物质ID | 468590769 |
| MDL编号 | MFCD08064035 |
技术规格
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 160 °C(dec.) |
| 最大吸收波长 | 716 nm |
GHS
相关法规
运输信息
| HS编码* | 2935.90-000 |
应用
Belinostat: A Class I, II and IV HDAC Inhibitor
Belinostat (PXD101) is a class I, II and IV histone deacetylase (HDAC) enzyme inhibitor with a broad antineoplastic activity. HDACs catalyze the removal of acetyl groups from the N-acetylated lysine residues of histones and some non-histone proteins. Histones are the basic protein building blocks of chromatins in the nucleus of a cell, which contain DNA coiled around the histone unit. They compact DNA into a smaller volume, and also play a role in DNA replication, repair, mitosis, and gene expression. HDAC inhibitors block angiogenesis, arrest cell growth, and lead to cell-cycle arrest and apoptosis in tumor cells. Belinostat has been used for the treatment of T-cell lymphoma (PTCL). (The product is for research purpose only.)
References
- Pharmacodynamic Response and Inhibition of Growth of Human Tumor Xenografts by the Novel Histone Deacetylase Inhibitor PXD101
- Activity of PXD101, a histone deacetylase inhibitor, in preclinical ovarian cancer studies
- Belinostat: First Global Approval (a review)
- Histone deacetylase inhibitors (HDACIs). Structure-activity relationships: history and new QSAR perspectives (a review)
- LC-MS/MS assay for the quantitation of the HDAC inhibitor belinostat and five major metabolites in human plasma
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