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CAS RN: 202189-78-4 | 产品编码: B5392
Bilastine
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| 产品编码 | B5392 |
| 纯度/分析方法 | >98.0%(T)(HPLC) |
| 分子式/分子量 | C__2__8H__3__7N__3O__3 = 463.62 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片）, 250MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 202189-78-4 |
| Reaxys-RN | 13851185 |
| PubChem物质ID | 354335500 |
| MDL编号 | MFCD09837814 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 199.0 to 203.0 °C |
物性（参考值）
| 熔点 | 202 °C |
| 水溶性 | 不溶 |
| 溶解性（不溶于） | 甲醇 |
GHS
相关法规
运输信息
| HS编码* | 2933.99-000 |
应用
Bilastine: A Selective Histamine H1 Receptor Antagonist
Bilastine is a selective histamine H1 receptor antagonist. On the other hand, the results of studies on bilastine confirmed the lack of significant antagonism against not only histamine H2 and H3 receptors but also serotonin, bradykinin, leukotriene D4, calcium, muscarinic M3-receptors, α1-adrenoceptors, and β2-adrenoceptors. Furthermore, bilastine do not cause sedation or interact with cytochrome P 450. Therefore, bilastine is used as a second generation H1-antihistamine for the treatment of allergic rhinitis and chronic urticarial. For your reference, [P2382] is a synthetic intermediate of bilastine.(The product is for research purpose only.)
References
- Preclinical pharmacology of bilastine, a new selective histamine H1 receptor antagonist. Receptor selectivity and in vitro antihistaminic activity
- In vivo pharmacological characterisation of bilastine, a potent and selective histamine H1 receptor antagonist
- Safety and efficacy of bilastine: a new H1-antihistamine for the treatment of allergic rhinoconjunctivitis and urticarial (a review)
- Histamine and H1-antihistamines: Celebrating a century of progress (a review)
- Application of Analytical Quality by Design concept for bilastine and its degradation impurities determination by hydrophilic interaction liquid chromatographic method
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