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CAS RN: 980-71-2 | 产品编码: B5167
Brompheniramine Maleate
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技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 %(total of Ion-Pair) |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 134.0 to 138.0 °C |
物性（参考值）
| 熔点 | 136 °C |
| 最大吸收波长 | 261 nm |
| 水溶性 | 可溶 |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H302 : Harmful if swallowed. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相关法规
| RTECS# | US4025000 |
运输信息
| HS编码* | 2933.39-000 |
应用
Brompheniramine Maleate: A First Generation Histamine H1 Receptor Antagonist
Brompheniramine maleate is a first generation histamine H1 receptor antagonist. Brompheniramine binds to a G protein-coupled form of the receptor and promotes a G protein-coupled inactive state of the H1 receptor that interferes with the Gq/11-mediated signaling. Brompheniramine permeates the blood-brain barrier causing drowsiness. Brompheniramine also has anticholinergic properties. For reference, we also have related first generation histamine H1 receptor antagonists, such as pheniramine maleate [P2271] (H instead of Br), chlorpheniramine maleate [C0873] (Cl instead of Br) and pyrilamine maleate [P2369]. (The product is for research purpose only.)
References
- Effect of pheniramine, chlorpheniramine and brompheniramine on stimulated blood platelets: structure-activity relationships
- Anticholinergic properties of brompheniramine, chlorpheniramine, and atropine in human nasal mucosa in vitro.
- Separation of brompheniramine enantiomers by capillary electrophoresis and study of chiral recognition mechanisms of cyclodextrins using NMR-spectroscopy, UV spectrometry, electrospray ionization mass spectrometry and X-ray crystallography
- Analysis of pharmaceutical preparations containing antihistamine drugs by micellar liquid chromatography
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