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CAS RN: 69304-47-8 | 产品编码: B3404
(E)-5-(2-Bromovinyl)-2'-deoxyuridine
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This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| 产品编码 | B3404 |
| 纯度/分析方法 | >98.0%(T)(HPLC) |
| 分子式/分子量 | C__1__1H__1__3BrN__2O__5 = 333.14 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷藏 (0-10°C) |
| 应避免的情况 | 加热 |
| 包装和容器 | 100MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 69304-47-8 |
| Reaxys-RN | 758153 |
| PubChem物质ID | 87561214 |
| Merck Index (14) | 1378 |
| MDL编号 | MFCD00058585 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Specific rotation [a]20/D | +8.0 to +10.0 deg(C=1, MeOH) |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 166 °C(dec.) |
| 比旋光度 [α]D | 9° (C=1,MeOH) |
GHS
相关法规
| RTECS# | YU7355000 |
运输信息
| HS编码* | 2940.00-000 |
应用
Brivudine (BVdU): A Nucleoside Analogue Anti-Herpesvirus Agent
Brivudine (BVdU) is a nucleoside analogue anti-herpesvirus agent, and is often used for treatment of herpes simplex virus-1 (HSV-1) and varicella-zoster virus (VZV) infections. Brivudine blocks the action of DNA polymerases, thus inhibiting viral replication. Brivudine owes its effect to preferential phosphorylation by virus-encoded thymidine kinase to its 5'-diphosphate form. After further conversion to triphosphate form, it acts as an inhibitor or alternate substrate for the viral DNA polymerase. Brivudine is also characterized by a well described fatal drug interaction with antitumor agents such as 5-fluorouracil (5-FU) [F0151] and its prodrugs. This is caused by the main metabolite, bromovinyluracil (BVU), irreversibly inhibiting the enzyme dihydropyrimidine dehydrogenase (DPD) which is necessary for inactivating 5-FU. (The product is for research purpose only.)
References
- (E)-5-(2-Bromovinyl)-2'-deoxyuridine: a potent and selective anti-herpes agent
- On the mechanism of selective inhibition of herpesvirus replication by (E)-5-(2-bromovinyl)-2'-deoxyuridine
- Discovery and development of BVDU (brivudine) as a therapeutic for the treatment of herpes zoster (a review)
- (E)-5-(2-Bromovinyl)-2'-deoxyuridine (BVDU) (a review)
参考文献
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