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CAS RN: 141433-60-5 | 产品编码: B0450
Berberine Chloride Hydrate
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| 产品编码 | B0450 |
| 纯度/分析方法 | >98.0%(T)(HPLC) |
| 分子式/分子量 | C__2__0H__1__8ClNO__4·xH__2O = 371.82 (as Anhydrous) |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 湿气 (吸湿) |
| CAS RN | 141433-60-5 |
| 相关CAS RN | 2086-83-1&633-65-8 |
| Reaxys-RN | 3836585 |
| PubChem物质ID | 87563487 |
| Merck Index (14) | 1154 |
| 颜色 | 75160 |
| MDL编号 | MFCD00011939 |
技术规格
| Appearance | White to Yellow to Orange powder to crystaline |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 %(calcd.on anh.substance) |
| Solubility in hot Water | almost transparency |
| Water | 8.0 to 12.0 % |
物性（参考值）
| 熔点 | 145 °C(dec.) |
GHS
相关法规
| RTECS# | DR9866400 |
运输信息
| HS编码* | 2939.79-000 |
应用
Autophagy research / Mitophagy research / ER-phagy research
References
- Berberine Induces Mitophagy through Adenosine Monophosphate-Activated Protein Kinase and Ameliorates Mitochondrial Dysfunction in PINK1 Knockout Mouse Embryonic Fibroblasts
- Berberine Rescues D-Ribose-Induced Alzheimer‘s Pathology via Promoting Mitophagy
- Berberine suppresses influenza virus-triggered NLRP3 inflammasome activation in macrophages by inducing mitophagy and decreasing mitochondrial ROS
- Berberine protects steatotic donor undergoing liver transplantation via inhibiting endoplasmic reticulum stress-mediated reticulophagy
- Berberine Ameliorates High Glucose-Induced Cardiomyocyte Injury via AMPK Signaling Activation to Stimulate Mitochondrial Biogenesis and Restore Autophagic Flux
应用
Bone research
References
- Berberine Promotes Osteoblast Differentiation by Runx2 Activation With p38 MAPK
- Berberine inhibits RANKL-induced osteoclast formation and survival through suppressing the NF-κB and Akt pathways
应用
Efflux pump inhibitor
Berberine can potentially inhibit a diverse range of different efflux pumps, including the resistance nodulation division (RND) family. 1,2)
References
- 1) Identification of natural compounds which inhibit biofilm formation in clinical isolates of Klebsiella pneumoniae
- 2) Effectiveness of efflux pump inhibitors as biofilm disruptors and resistance breakers in gram-negative (ESKAPEE) bacteria
应用
Berberine Chloride: An Isoquinoline Alkaloid with Multispectrum Activities
Berberine chloride, an isoquinoline alkaloid extracted from Goldenseal (Hydrastis canadensis L.) and many other plants, has been used in Traditional Chinese and Indian (Ayurvedic) medicines for its antimicrobial and antiprotozoal properties.1) Recent pharmacological studies on berberine have revealed its various pharmacological activities,1) such as anti-cancer,2) anti-inflammatory,3) anti-arrhythmic,4) anti-diabetic,5,6) cholesterol-lowering7) and neuroprotective effects,8) yet the exact mechanisms are unknown. However, it is reported that berberine is able to activate an enzyme called Adenosine Monophosphate-Activated Protein Kinase (AMPK).5,6) (The product is for research purpose only.)
References
- 1)Berberine: a potential phytochemical with multispectrum therapeutic activities (a review)
- 2)Berberine and Coptidis Rhizoma as novel antineoplastic agents: A review of traditional use and biomedical investigations (a review)
- 3)The anti-inflammatory potential of berberine in vitro and in vivo
- 4)Cardiovascular actions of berberine (a review)
- 5)Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states
- 6)Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: A mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action
- 7)Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins
- 8)Berberine: a plant alkaloid with therapeutic potential for central nervous system disorders (a review)
参考文献
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