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Notice of Discontinuing the Use of Password-Protected Compressed Files | Product Document Searching Made Easy by 2D Code! | TCI Life Science News February 2025 | [Product Highlights] Chemiluminescent Reagents for... | Various analytical charts can be searched on each product detail page and Product Document Search (The kinds of analytical charts differ by product)
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CAS RN: 55-21-0 | 产品编码: B0012
Benzamide
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技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 99.0 % |
| Melting point | 127.0 to 130.0 °C |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 128 °C |
| 沸点 | 288 °C |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H302 : Harmful if swallowed. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相关法规
| RTECS# | CU8700000 |
运输信息
| HS编码* | 2924.29-000 |
应用
Benzamide: An Inhibitor of Poly (ADP-Ribose) Polymerase (PARP) Enzymes
Genomic instability is a hallmark of cancer and is often the result of altered DNA repair capabilities in tumor cells. Poly (ADP-ribose) polymerases (PARPs) are enzymes responsible for DNA damage detection and repair factor recruitment. PARP inhibitors are able to interact with the binding site for the PARP cofactor NAD+ and trap PARP on DNA, and induce cell death through replication stress-induced mitotic catastrophe. It has been reported that benzamide is a PARP inhibitor and has neuroprotective effects. (The product is for research use only.)
References
- Benzamide, an inhibitor of poly(ADP-ribose) polymerase, attenuates methamphetamine-induced dopamine neurotoxicity in the C57Bl/6N mouse
- Poly(ADP-ribose) polymerase inhibitors protect against MPTP-induced depletions of striatal dopamine and cortical noradrenaline in C57B1/6 mice
- Chapter 10, Clinical Development of the Nicotinamides and Benzamides Involving PARP as a Molecular Target (a review)
参考文献
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