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CAS RN: 129639-79-8 | 产品编码: A3213
Abafungin
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纯度/分析方法: >95.0%(HPLC)
别名：
- 阿巴芬净
- N-[4-[2-(2,4-二甲基苯氧基)苯基]-2-噻唑基]-1,4,5,6-四氢-2-嘧啶胺
- 4-[2-(2,4-二甲基苯氧基)苯基]-N-(1,4,5,6-四氢嘧啶-2-基)噻唑-2-胺
- N-[4-[2-(2,4-Dimethylphenoxy)phenyl]-2-thiazolyl]-1,4,5,6-tetrahydro-2-pyrimidinamine
- 4-[2-(2,4-Dimethylphenoxy)phenyl]-N-(1,4,5,6-tetrahydropyrimidin-2-yl)thiazol-2-amine
产品文档：
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Melting point | 197.0 to 201.0 °C |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 199 °C |
GHS
相关法规
运输信息
| HS编码* | 2934.10-000 |
应用
Abafungin: A Thiazole Type Antifungal Agent with a Novel Mechanism of Action
Abafungin is a broad-spectrum thiazole type antifungal agent with a novel mechanism of action. Mode of action studies suggested that inhibits the enzyme sterol-C-24-methyltransferase which catalyzes the transmethylation at the C-24 position of the sterol side chain. In addition, abafungin directly impairs the fungal cell membrane.
References
- Modes of Action of the New Arylguanidine Abafungin beyond Interference with Ergosterol Biosynthesis and in vitro Activity against Medically Important Fungi
- Thiazoles: a valuable insight into the recent advances and biological activities (a review)
- Bioactive thiazole and benzothiazole derivatives (a review)
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技术规格
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