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CAS RN: 55079-83-9 | 产品编码: A3097
Acitretin
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| 规格 | 单价 | 同一天 | 2-3个工作日 | 数量 |
|---|---|---|---|---|
| 50MG |
S$129.00
|
17 | 4 |
|
| 250MG |
S$399.00
|
34 | 4 |
|
| 产品编码 | A3097 |
| 纯度/分析方法 | >98.0%(T)(HPLC) |
| 分子式/分子量 | C__2__1H__2__6O__3 = 326.44 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷冻 (<0°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 光,空气,加热 |
| 包装和容器 | 250MG-Glass Bottle with Plastic Insert （查看图片）, 50MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 55079-83-9 |
| Reaxys-RN | 2158933 |
| PubChem物质ID | 354335416 |
| Merck Index (14) | 112 |
| MDL编号 | MFCD00866632 |
技术规格
| Appearance | Light yellow to Yellow to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
物性（参考值）
| 熔点 | 230 °C |
| 最大吸收波长 | 352(MeOH) nm |
GHS
| 象形图 |
|
| 信号词 | Danger |
| 危险性说明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. H360 : May damage fertility or the unborn child. H410 : Very toxic to aquatic life with long lasting effects. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P391 : Collect spillage. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P405 : Store locked up. |
相关法规
运输信息
| UN编号 | UN3077 |
| 类别 | 9 |
| 包装类别 | III |
| HS编码* | 2918.99-000 |
应用
Acitretin: A Retinoic Acid Derivative that is an Active Metabolite of Etretinate
Acitretin is a retinoic acid (vitamin A acid) [R0064] derivative that is the major active metabolite of etretinate [E1293]. Acitretin s used for the treatment of severe psoriasis and other dyskeratoses, but the precise mechanism of action of it is not fully understood. However, the pharmacological profile of acitretin suggests that it acts by normalizing pathological changes in epidermal and dermal skin, particularly inhibiting hyperkeratinization and cell differentiation. In addition, acitretin reportedly has teratogenic potential. (The product is for research purpose only.)
References
- Effects of 13-cis-retinoic acid, all-trans-retinoic acid, and acitretin on the proliferation, lipid synthesis and keratin expression of cultured human sebocytes in vitro
- Acitretin: a review of its pharmacology and therapeutic use
- Systemic retinoids in chemoprevention of non-melanoma skin cancer (a review)
- Acitretin in dermatology: a review
- Comparative teratogenicity of nine retinoids in the rat
参考文献
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