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CAS RN: 102121-60-8 | 产品编码: A3082
AM580
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| 产品编码 | A3082 |
| 纯度/分析方法 | >98.0%(HPLC) |
| 分子式/分子量 | C__2__2H__2__5NO__3 = 351.45 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| 包装和容器 | 100MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 102121-60-8 |
| Reaxys-RN | 3565084 |
| PubChem物质ID | 468590144 |
| MDL编号 | MFCD00673916 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
物性（参考值）
| 熔点 | 260 °C |
| 最大吸收波长 | 283(EtOH(95vol%)) nm |
GHS
相关法规
| RTECS# | DH6834890 |
运输信息
| HS编码* | 2924.29-000 |
应用
AM580: A Retinoic Acid Receptor-α (RARα)-Selective Agonist
AM580, a stable retinobenzoic acid derivative, is a retinoic acid receptor-α (RARα)-selective agonist. Retinoids regulate a wide variety of essential biological processes. RARα is a member of retinoic acid receptors (RARs) which act as ligand-activated transcription factors controlling the expression of a number of target genes. It is reported that AM580 promotes the reprogramming of somatic cells to induced pluripotent stem cells and inhibits tumor cell proliferation. (The product is for research purpose only.)
References
- AM580, a stable benzoic derivative of retinoic acid, has powerful and selective cyto-differentiating effects on acute promyelocytic leukemia cells
- Retinobenzoic acids. 1. Structure-activity relationships of aromatic amides with retinoidal activity
- The Retinoic Acid Receptor-α mediates human T-cell activation and Th2 cytokine and chemokine production
- Novel non-carboxylic acid retinoids: 1,2,4-Oxadiazol-5-one derivatives
- Rapid and efficient reprogramming of somatic cells to induced pluripotent stem cells by retinoic acid receptor gamma and liver receptor homolog 1
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