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CAS RN: 104075-48-1 | 产品编码: A2956
Atipamezole Hydrochloride
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| 产品编码 | A2956 |
| 纯度/分析方法 | >98.0%(T)(HPLC) |
| 分子式/分子量 | C__1__4H__1__6N__2·HCl = 248.75 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| 包装和容器 | 100MG-Glass Bottle with Plastic Insert （查看图片）, 25MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 104075-48-1 |
| 相关CAS RN | 104054-27-5 |
| Reaxys-RN | 8164642 |
| PubChem物质ID | 354334070 |
| Merck Index (14) | 861 |
| MDL编号 | MFCD06407819 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 218.0 to 222.0 °C |
物性（参考值）
| 熔点 | 220 °C |
| 水溶性 | 可溶 |
| 溶解性（可溶于） | 乙醇 |
| 溶解性（不溶于） | 丙酮 |
GHS
相关法规
| RTECS# | NI6139000 |
运输信息
| HS编码* | 2933.29-000 |
应用
Atipamezole: An α2-Adrenoceptor Antagonist
Atipamezole hydrochloride is a potent and selective α2-adrenoceptor antagonist with an imidazole structure. In animals, it promotes the release of the neurotransmitter noradrenaline in the central as well as in the peripheral nervous systems. The α2/α1 selectivity ratio are considerably higher than those of yohimbine hydrochloride [Y0002]. Unlike many other α2-adrenoceptor antagonists, atipamezole has negligible affinity for 5-HT1A receptors. Atipamezole hydrochloride is used for the reversal of an α2-agonist (e.g. xylazine hydrochloride [X0059]) induced sedation in animals. (The product is for research purpose only.)
References
- Highly selective and specific antagonism of central and peripheral α2-adrenoceptors by atipamezole
- Evaluation of the effects of a specific α2-adrenoceptor antagonist, atipamezole, on α1- and α2-adrenoceptor subtype binding, brain neurochemistry and behavior in comparison with yohimbine
- Actions of α2 adrenoceptor ligands at α2A and 5-HT1A receptors: the antagonist, atipamezole, and the agonist, dexmedetomidine, are highly selective for α2A adrenoceptors
- Pharmacological properties, central nervous system effects, and potential therapeutic applications of atipamezole, a selective α2-adrenoceptor antagonist
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