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CAS RN: 138112-76-2 | 产品编码: A2606
Agomelatine
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| 产品编码 | A2606 |
| 纯度/分析方法 | >98.0%(HPLC)(N) |
| 分子式/分子量 | C__1__5H__1__7NO__2 = 243.31 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷藏 (0-10°C) |
| 应避免的情况 | 加热 |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 138112-76-2 |
| Reaxys-RN | 5813634 |
| PubChem物质ID | 253661921 |
| Merck Index (14) | 190 |
| MDL编号 | MFCD00916659 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Melting point | 108.0 to 112.0 °C |
物性（参考值）
| 熔点 | 110 °C |
| 溶解性（可溶于） | 甲醇 |
GHS
相关法规
| RTECS# | AC5956323 |
运输信息
| HS编码* | 2924.29-000 |
应用
Agomelatine: A Melatonergic MT1 and MT2 Receptor Agonist with Serotonin 5-HT2C Receptor Antagonist Activity
Agomelatine is a melatonergic MT1 and MT2 receptor agonist with serotonin 5-HT2C receptor antagonist activity. Stimulation of melatonergic (MT1 and MT2) receptors in suprachiasmatic nucleus of hypothalamus by agomelatine leads to the restoration of disturbed circadian rhythm. Selective binding to serotonin 5HT2C receptors by agomelatine leads to an increase in norepinephrine [A0906(Bitartrate)] and dopamine [A0305(Hydrochloride)] levels.
References
- Novel naphthalenic ligands with high affinity for the melatonin receptor
- The novel melatonin agonist agomelatine (S20098) is an antagonist at 5-hydroxytryptamine2C receptors, blockade of which enhances the activity of frontocortical dopaminergic and adrenergic pathways
- Effect of Agomelatine in the Chronic Mild Stress Model of Depression in the Rat
- Agomelatine, the first melatonergic antidepressant: discovery, characterization and development
- A systematic, updated review on the antidepressant agomelatine focusing on its melatonergic modulation
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