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CAS RN: 147403-03-0 | 产品编码: A2601
Azilsartan
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| 产品编码 | A2601 |
| 纯度/分析方法 | >98.0%(T)(HPLC) |
| 分子式/分子量 | C__2__5H__2__0N__4O__5 = 456.46 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷藏 (0-10°C) |
| 应避免的情况 | 加热 |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片）, 200MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 147403-03-0 |
| Reaxys-RN | 7673311 |
| PubChem物质ID | 253660226 |
| MDL编号 | MFCD00916395 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
物性（参考值）
| 熔点 | 188 °C(dec.) |
| 水溶性 | 不溶 |
| 溶解性（微溶于） | 甲醇 |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H361 : Suspected of damaging fertility or the unborn child. H413 : May cause long lasting harmful effects to aquatic life. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
相关法规
运输信息
| HS编码* | 2934.99-000 |
应用
Azilsartan: a Strong Angiotensin II Type 1 (AT1) Receptor Blocker (or Antagonist) (abbrev: ARB)
Azilsartan, an angiotensin II type 1 (AT1) receptor blocker (or antagonist) (abbrev: ARB), combines strongly with human AT1 receptor. Compared to other ARB, dissociation of azilsartan from the receptor is extremely slow. It is the active metabolite of azilsartan medoxomil. For your reference, [M2797] and [M3197] are synthetic intermediates of azilsartan. (The product is for research purpose only.)
References
- Synthesis and Angiotensin II Receptor Antagonistic Activities of Benzimidazole Derivatives Bearing Acidic Heterocycles as Novel Tetrazole Bioisosteres
- In vitro antagonistic properties of a new angiotensin type 1 receptor blocker, azilsartan, in receptor binding and function studies
- Molecular and cellular effects of azilsartan: a new generation angiotensin II receptor blocker
- Antihypertensive, insulin-sensitising and renoprotective effects of a novel, potent and long-acting angiotensin II type 1 receptor blocker, azilsartan medoxomil, in rat and dog models
- Differential pharmacology and benefit/risk of azilsartan compared to other sartans
参考文献