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Published TCIMAIL newest issue No.197 | Notice of Discontinuing the Use of Password-Protected Compressed Files | Product Document Searching Made Easy by 2D Code! | TCI Life Science News December 2024 | [TCIPracticalExample] Reduction of Amide Group Using... | Various analytical charts can be searched on each product detail page and Product Document Search (The kinds of analytical charts differ by product)
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CAS RN: 2627-69-2 | 产品编码: A2528
| 产品编码 | A2528 |
| 纯度/分析方法 | >98.0%(HPLC) |
| 分子式/分子量 | C__9H__1__4N__4O__5 = 258.23 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷冻 (<0°C) |
| 应避免的情况 | 加热 |
| 包装和容器 | 50MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 2627-69-2 |
| Reaxys-RN | 38255 |
| PubChem物质ID | 253659575 |
| Merck Index (14) | 16 |
| MDL编号 | MFCD00869751 |
技术规格
| Appearance | White to Light yellow to Light red powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Specific rotation [a]20/D | -61.0 to -66.0 deg(C=1、H2O) |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 212 °C |
| 比旋光度 [α]D | -63° (C=1,H2O) |
| 最大吸收波长 | 265(NaOH) nm |
GHS
| 象形图 |
|
| 信号词 | Warning |
| 危险性说明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防范说明 | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
相关法规
运输信息
| HS编码* | 2934.99-000 |
应用
Autophagy research
References
- AICA-riboside induces apoptosis of pancreatic beta cells through stimulation of AMP-activated protein kinase
- Inhibition of Hepatocytic Autophagy by Adenosine, Aminoimidazole-4-carboxamide Riboside, and N6-Mercaptopurine Riboside. EVIDENCE FOR INVOLVEMENT OF AMP-ACTIVATED PROTEIN KINASE
应用
Acadesine (AICAR): AMP-Activated Protein Kinase Activator
5-Aminoimidazole-4-carboxamide 1-β-D-ribofuranoside (Acadesine or AICAR) has been extensively used in vitro and in vivo to activate AMP-activated protein kinase (AMPK). AMPK stimulates energy production via glucose and lipid metabolism, whereas it inhibits energy consuming functions, such as protein and cholesterol synthesis. Therefore, acadesine may have applications in treating disorders such as type 2 diabetes and Alzheimer's disease. Recently, it has been shown that acadesine induces leukemia apoptosis. (The product is for research purpose only.)
References
- 5-Aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells?
- J. M. Corton, J. G. Gillespie, S. A. Hawley, D. G. Hardie, Eur. J. Biochem. 1995, 229, 558.
- AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle
- G. F. Merrill, E. J. Kurth, D. G. Hardie, W. W. Winder, Am. J. Physiol. 1997, 273, E1107.
- Evidence for 5' AMP-activated protein kinase mediation of the effect of muscle contraction on glucose transport
- T. Hayashi, M. F. Hirshman, E. J. Kurth, W. W. Winder, L. J. Goodyear, Diabetes 1998, 47, 1369.
- Knockout of the α2 but Not α1 5'-AMP-activated Protein Kinase Isoform Abolishes 5-Aminoimidazole-4-carboxamide-1-β-4-ribofuranoside- but Not Contraction-induced Glucose Uptake in Skeletal Muscle
- 5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranoside Inhibits Cancer Cell Proliferation in Vitro and in Vivo via AMP-activated Protein Kinase
- AMP-activated protein kinase and muscle glucose uptake (a review)
- AMP-activated protein kinase: a potential player in Alzheimer's disease (a review)
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