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CAS RN: 4023-02-3 | 产品编码: A2055
1-Amidinopyrazole Hydrochloride
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| 规格 | 单价 | 同一天 | 2-3个工作日 | 数量 |
|---|---|---|---|---|
| 5G |
S$43.50
|
16 | ≥40 |
|
| 25G |
S$129.00
|
38 | ≥40 |
|
技术规格
| Appearance | White to Yellow to Orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 165.0 to 169.0 °C |
物性（参考值）
| 熔点 | 167 °C |
GHS
| 象形图 |
|
| 信号词 | Warning |
| 危险性说明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防范说明 | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
相关法规
运输信息
| HS编码* | 2933.19-000 |
应用
TCI Practical Example: Guanidinylation of Amine Using Praxadine
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Used Chemicals
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Procedure
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A solution of 4-bromophenethylamine (200 mg, 1.00 mmol), DIEA (509 µL, 3.00 mmol) and praxadine (147 mg, 1.00 mmol) in DMF (1.7 mL) was stirred at ambient temperature for 2 days. The reaction mixture was concentrated and the residue was washed with dichloromethane/2-propanol (4:1 (vol/vol)). The guanidinylated compound 1 was obtained as a pale yellow solid (164 mg, 67% yield.) after filtration.
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Experimenter’s Comments
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The reaction mixture was monitored by LC/MS.
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Analytical Data
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Guanidinylated Compound 1
1H NMR (270 MHz, DMSO-d6); δ 7.57 (t, J = 6.3 Hz, 1H), 7.52 (d, J = 8.4 Hz, 2H), 7.25 (d, J = 8.4 Hz, 2H), 6.99 (brs, 3H), 3.35 (q, J = 6.3 Hz, 2H), 2.76 (t, J = 6.3 Hz, 2H).
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Lead Reference
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- Synthesis and pharmacological characterization of a new benzoxazole derivative as a potent 5-HT3 receptor agonist
应用
Guanidinylation
Typical Procedure:
1-Amidinopyrazole hydrochloride (1 g, 6.8 mmol) is added to a solution of 2-(benzoxazol-2-yl)ethylamine (1.1 g, 6.7 mmol) and diisopropylethylamine (4.75 mL, 27 mmol) in DMF (10 mL). The reaction mixture is stirred at room temperature under N2 for 24 h. Subsequently, diethylether (75 mL) is added, the upper layer is decanted and the remaining oil solidified by treatment with CH2Cl2. The solid is collected, washed with diethylether, CH2Cl2, and CHCl3 : i-PrOH (4 : 1) and dried to yield the product (0.86 g, Y. 52.6%).
1-Amidinopyrazole hydrochloride (1 g, 6.8 mmol) is added to a solution of 2-(benzoxazol-2-yl)ethylamine (1.1 g, 6.7 mmol) and diisopropylethylamine (4.75 mL, 27 mmol) in DMF (10 mL). The reaction mixture is stirred at room temperature under N2 for 24 h. Subsequently, diethylether (75 mL) is added, the upper layer is decanted and the remaining oil solidified by treatment with CH2Cl2. The solid is collected, washed with diethylether, CH2Cl2, and CHCl3 : i-PrOH (4 : 1) and dried to yield the product (0.86 g, Y. 52.6%).
References
- P. L. Lopez-Tudanca, L. Labeaga, A. Innerarity, L. Alonso-Cires, I. Tapia, R. Mosquera, A. Orjales, Bioorg. Med. Chem. 2003, 11, 2709.
- Y. Zhang, A. J. Kennan, Org. Lett. 2001, 3, 2341.
- A. Porcheddu, G. Giacomelli, A. Chighine, S. Masala, Org. Lett. 2004, 6, 4925.
参考文献
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