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CAS RN: 56-12-2 | 产品编码: A0282
4-Aminobutyric Acid
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技术规格
| Appearance | White powder to crystaline |
| Purity(Nonaqueous Titration) | min. 99.0 % |
| Solubility in Water | almost transparency |
物性（参考值）
| 熔点 | 195 °C(dec.) |
GHS
相关法规
| RTECS# | ES6300000 |
运输信息
| HS编码* | 2922.49-000 |
应用
GABA: A Major Inhibitory Neurotransmitter in Nervous System
4-Aminobutyric acid (γ-aminobutyric acid or GABA) is a major inhibitory neurotransmitter in nervous system, the first report by Hayashi et al. in 1950s. GABA is present not only in the central nervous system but also in the peripheral nervous system. GABA plays the principal role in modulating neuronal excitability throughout the nervous system. Moreover, GABA is involved in a variety of biological functions such as proliferation, differentiation, migration and growth of neurons. GABA functions appear to be triggered by binding of GABA to its ionotropic receptors (GABAA and GABAC) which are ligand-gated chloride channels, and its metabotropic receptors GABAB which are coupled to G-proteins.
References
- Inhibition and excitation due to gamma-aminobutyric acid in the central nervous system.
- Excitatory actions of GABA during development: the nature of the nurture (a review)
- GABA and GABA receptors in the central nervous system and other organs (a review)
- GABA: a pioneer transmitter that excites immature neurons and generates primitive oscillations (a review)
- Extracellular level of GABA and Glu: in vivo microdialysis-HPLC measurements
- Determination and Comparison of γ-Aminobutyric Acid (GABA) Content in Pu-erh and Other Types of Chinese Tea
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