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Helioxanthin Analogue (TH): Promoting Osteogenic Differentiation
To effectively treat serious bone defects using bone regenerative medicine, there is a need for the development of a small chemical compound that potently induces bone formation. The helioxanthin analogue (TH) is an osteogenic small compound that was first reported by Ohba et al.1) In their reports, TH not only stimulates osteoblast differentiation of osteoblast precursors, but also enhances bone regeneration in rodent bone defect models.2,3) The osteogenic effects are also observed in mouse and human pluripotent stem cells4,5) as well as human dental pulp stem cells.6)
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References
- 1)A novel osteogenic helioxanthin-derivative acts in a BMP-dependent manner
- 2)Enhancement of bone formation ex vivo and in vivo by a helioxanthin-derivative
- 3)Bone healing by sterilizable calcium phosphate tetrapods eluting osteogenic molecules
- 4)Stepwise Differentiation of Pluripotent Stem Cells into Osteoblasts Using Four Small Molecules under Serum-free and Feeder-free Conditions
- 5)Three-dimensional system enabling the maintenance and directed differentiation of pluripotent stem cells under defined conditions
- 6)Bone regeneration by human dental pulp stem cells using a helioxanthin derivative and cell-sheet technology
