Maintenance Notice (10:30 PM January 4 - 8:00 AM January 5, 2025 UTC): This website is scheduled to be unavailable due to maintenance. We appreciate your patience and understanding.
Published TCIMAIL newest issue No.197 | Notice of Discontinuing the Use of Password-Protected Compressed Files | Various analytical charts can be searched on each product detail page and Product Document Search (The kinds of analytical charts differ by product)
Maximum quantity allowed is 999
Please select the quantity
Enantioselective Synthesis of Bicyclo Compounds Catalyzed by Rhodium and Benzoic Acid
Tanaka et al. have reported the synthesis of bicyclo[3.1.0]hexanes by the enantioselective cycloisomerization of 1,6-enynes using rhodium and benzoic acid catalysts. According to their results, the enantioselective cycloisomerization of 1,6-enynes possessing carbonyl groups at the enyne linkage proceeds by using [Rh(cod)2]BF4, (S)-Segphos and benzoic acid as catalysts successfully giving 2-alkylidenebicyclo[3.1.0]hexanes. Bicyclo[3.1.0]hexane skeletons are found as core structures of natural products, so this reaction has attracted much attention as a useful synthetic method for these bicyclo compounds. Furthermore, they have also reported the one-pot synthesis of bicyclo lactones by the enantioselective cycloisomerization of 1,6-enynes followed by the tosyl acid-promoted lactonization.
